摘要
目的探讨cyclin G1表达与原发性肝癌放疗疗效的关系。方法免疫组织化学检测68例接受放疗的原发性肝癌活检标本中cyclin G1的表达,卡方检验分析cyclin G1与临床病理特征的关系,Kaplan-Meier评估cyclin G1表达与患者生存期之间的关系,单因素及多因素分析各临床参数对生存期的影响。结果临床病理特征分析显示,cyclin G1表达与门脉癌栓、临床分期及甲胎蛋白相关。生存分析显示cyclin G1低表达的患者总生存率及无进展生存率均显著高于cyclin G1高表达组(P<0.05)。多因素分析显示cyclin G1高表达是肝癌患者无进展生存率的独立危险因素。结论cyclin G1高表达是肝癌放疗患者不良预后因素。
Objective To investigate the correlation between cyclin G1 expression and the efficacy of radiotherapy on HCC.Methods The expression of cyclin G1 in biopsy specimens of 68 patients who received radiotherapy was detected by immunochemistry.The correlation between cyclin G1 expression and clinicopathological characteristics was analyzed by chi-square test.The correlation between cyclin G1 expression and OS or PFS was evaluated by Kaplan-Meier analysis.Univariate and multivariate analyses were used for the relation between clinicopathological characteristics and OS or PFS.Results The expression of cyclin G1 was related to portal vein tumor embolus,clinical stage and alpha fetoprotein.Survival analysis showed that the OS and PFS of patients with low expression of cyclin G1 were significantly higher than those with high cyclin G1 expression(P<0.05).Multivariate analysis showed that cyclin G1 was an independent risk factor for DFS of patients with HCC.Conclusion High expression of cyclin G1 is an adverse prognostic factor for HCC patients who received radiotherapy.
作者
许刚
卜珊珊
王修身
葛红
XU Gang;BU Shanshan;WANG Xiushen;GE Hong(Department of Radiation Oncology,Affiliated Cancer Hospital of Zhengzhou University,Zhengzhou 450008,China)
出处
《肿瘤防治研究》
CAS
CSCD
2021年第10期958-962,共5页
Cancer Research on Prevention and Treatment
基金
河南省科技厅重点研发及推广专项(192102310102)。
关键词
cyclin
G1
肝癌
放射治疗
预后
cyclin G1
Hepatocellular carcinoma
Radiotherapy
Prognosis
