摘要
随着手术导航技术的快速发展和临床应用,靶向近红外荧光(NIRF)术中导航正在向临床应用快速转化。传统的吲哚菁绿(ICG)等荧光染料难以满足靶向荧光手术的需求,但其所用手术设备可直接用于近红外Ⅰ区靶向染料引导的手术导航。前列腺特异性膜抗原(PSMA)靶向NIRF染料中的配体也由抗体、多肽、小分子向多模态和可被PSMA酶活性激活染料转变。抗体偶联NIRF染料研究最早,目前已经进入临床试验阶段。PSMA PET的广泛应用使其相关配体正在迅速向荧光手术转化。因此,本文现就PSMA靶向手术导航技术在前列腺癌中的研究进展进行综述。
With rapid development and clinical application of surgery navigation system,targeted surgery navigation is rapidly transforming into clinical use,which is the developing trend of fluorescence guided surgery(FGS).Traditional fluorescent dyes such as indocyanine green(ICG)are difficult to meet the needs of targeted FGS,but the surgical equipment can be directly used for targeted near-infrared(NIR)FGS.PSMA targeted NIRF dyes have been developed from antibody/peptide/small molecule conjugated NIRF dyes to multi-modal or activatable NIRF dyes.Some prostate specific membrane antigen(PSMA)-targeted antibody conjugated NIR fluorescent dyes have entered the clinical trial stage.With the wide application of PSMA PET,the related ligands are rapidly transforming into fluorescent surgery.In this article,the research progress of PSMA targeted surgery navigation in prostate cancer is reviewed.
作者
冯科森
焦健华
张景良
秦卫军
FENG Kesen;JIAO Jianhua;ZHANG Jingliang;QIN Weijun(Medical Team of 61035 PLA,Beijing 102205;Department of Urology,Xijing Hospital,Air Force Medical University,Xi an 710032,China)
出处
《现代泌尿外科杂志》
CAS
2021年第10期881-886,共6页
Journal of Modern Urology
基金
国家自然科学基金(No.81772734)
陕西省创新能力支撑计划(No.2020PT-021)
陕西科技创新团队(No.2021TD-39)。
关键词
前列腺癌
前列腺特异性膜抗原
靶向
荧光
放射性核素
prostate cancer
prostate specific membrane antigen
targeted
fluorescence
radionuclide
