摘要
目的对非小细胞肺癌患者体内的程序性死亡因子配体1(PD-L1)和表皮生长因子受体(EGFR)表达情况进行研究,从而分析以上两种指标与疾病的相关性。方法以该院2018年6月—2020年1月期间收治的60例非小细胞肺癌患者为研究对象,对组织标本进行检测,以上患者简称观察组,再选取同一时期来该院治疗的良性病变患者40例,对其组织标本进行检测,以上患者简称对照组。比较两组患者中PD-L1和EGFR的阳性表达率,以及PD-L1和EGFR的表达与肺癌的相关性进行研究。结果观察组患者的PD-L1与EGFR的阳性表达率分别为:81.7%(49/60),55.0%(33/60),对照组患者的的PD-L1与EGFR的阳性表达率分别为:10.0%(4/40),7.5%(3/40),差异有统计学意义(χ^(2)=49.485、23.503,P<0.05);PD-L1的表达和临床分期情况以及淋巴结转移相关(P<0.05),PD-L1的表达和性别、年龄、病理分级以及肿瘤大小无关(P>0.05);EGFR的表达与患者的性别、年龄、疾病的临床分期、病理分级、肿瘤大小以及淋巴结转移情况无关(P>0.05)。结论PD-L1与EGFR的表达和非小细胞肺癌的病理情况息息相关,可以联合检测两种项目,可以有效判断淋巴结转移情况以及病理分期。
Objective To study the expression of programmed death factor ligand 1(PD-L1)and epidermal growth factor receptor(EGFR)in patients with non-small cell lung cancer,so as to analyze the correlation between the above two indicators and the disease.Methods From June 2018 to January 2020 in the hospital,60 cases of non-small cell lung cancer patients with fingers were tested.The tissue samples were tested.The above patients were referred to as the observation group.Then the benign patients who came to the hospital for treatment during the same period were selected.Forty patients with disease,their tissue samples were tested,and the above patients were referred to as the control group.Compare the positive expression rates of PD-L1 and EGFR in the two groups of patients,as well as the correlation between the expression of PD-L1 and EGFR and lung cancer.Results The positive expression rates of PD-L1 and EGFR in the observation group were 81.7%(49/60),55.0%(33/60),and the positive expression rates of PD-L1 and EGFR in the control group were respectively:10.0%(4/40),7.5%(3/40),the difference was statistically significant(χ^(2)=49.485,23.503,P<0.05);PD-L1 expression was closely related to clinical stage and lymph node metastasis(P<0.05),the expression of PD-L1 had nothing to do with gender,age,pathological grade and tumor size(P>0.05);the expression of EGFR had nothing to do with the patient's gender,age,clinical stage of the disease,pathological grade,tumor size,and lymph node metastasis(P>0.05).Conclusion The expression of PD-L1 and EGFR is closely related to the pathological conditions of non-small cell lung cancer.The two items can be combined to detect lymph node metastasis and pathological staging.
作者
罗小红
朱本玲
LUO Xiaohong;ZHU Benling(Department of Pathology,People's Hospital of Changshou District,Chongqing,401220 China)
出处
《世界复合医学》
2021年第8期95-98,共4页
World Journal of Complex Medicine
关键词
程序性死亡因子配体1
表皮生长因子受体
非小细胞肺癌
阳性表达率
Programmed death factor ligand 1
Epidermal growth factor receptor
Non-small cell lung cancer
Positive expression rate
