摘要
目的:分析小青龙汤合六君子汤加减在老年慢性阻塞性肺疾病(COPD)急性加重期(痰浊阻肺证)并肺部感染的疗效。方法:选取2017年3月至2019年11月江西省中西医结合医院收治124例老年COPD急性加重期(痰浊阻肺证)并肺部感染患者,随机数字表法分为对照组(常规西药治疗)和观察组(常规西药+小青龙汤合六君子汤加减治疗),各62例。比较两组临床疗效、治疗前后肺功能、治疗前后的血清炎症因子水平、不良反应发生情况。结果:治疗前两组的第一秒用力呼吸容积(FEV1)、用力肺活量(FVC)、第一秒用力呼气容积占用力肺活量的比值(FEV1/FVC)相比差异无统计学意义(P>0.05);治疗后两组的FEV1、FVC、FEV1/FVC较治疗前均显著升高(P<0.05),且观察组显著高于对照组(P<0.05);治疗后,观察组总有效率显著高于对照组(P<0.05);治疗前两组血清白细胞介素8(IL-8)、肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)相比差异无统计学意义(P>0.05);治疗后两组的血清IL-8、TNF-α、hs-CRP较治疗前均显著降低(P<0.05),且观察组显著低于对照组(P<0.05);两组不良反应发生率相比差异无统计学意义(P>0.05)。结论:对老年COPD急性加重期(痰浊阻肺证)并肺部感染患者在常规西药治疗的同时给予小青龙汤合六君子汤加减可改善其肺功能,提高临床疗效,减轻炎症反应,且不会增加不良反应发生率。
Objective:To analyze the effect of Xiaoqinglong decoction and Liujunzi decoction addition and subtraction on pulmonary infection in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(COPD)(syndrome of turbid phlegm obstructing lung).Methods:A total of 124 elderly patients with acute exacerbation of COPD(syndrome of turbid phlegm obstructing lung)complicated with pulmonary infection admitted to Jiangxi Province Hospital of Integrated Traditional Chinese and Western Medicine from March 2017 to November 2019 were selected and randomly divided into control group(conventional western medicine treatment)and observation group(conventional western medicine+Xiaoqinglong decoction combined with Liujunzi decoction treatment),62 cases for each group.The clinical efficacy,pulmonary function before and after treatment,serum inflammatory factor levels before and after treatment,and adverse reactions were compared between the two groups.Results:Before treatment,the differences in the forced respiratory volume in the first second(FEV1),forced vital capacity(FVC)and the ratio of forced expiratory volume in the first second to forced vital capacity(FEV1/FVC)between the two groups had no statistical significance(P>0.05);after treatment,the FEV1,FVC and FEV1/FVC in the two groups were significantly higher than those before treatment(P<0.05),and the observation group was significantly higher than the control group(P<0.05);after treatment,the effective rate was significantly higher than the control group(P<0.05);before treatment,the differences in the serum interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)and high-sensitivity C-reactive protein(hs-CRP)between the two groups had no statistical significance(P>0.05);after treatment,the serum IL-8,TNF-αand hs-CRP in the two groups were significantly lower than those before treatment(P<0.05),and the observation group was significantly lower than the control group(P<0.05);the difference in the incidence rate of adverse reactions between the two groups had no statistical significance(P>0.05).Conclusion:Xiaoqinglong decoction combined with Liujunzi decoction can improve the pulmonary function,improve the clinical efficacy of acute exacerbation of COPD(syndrome of turbid phlegm obstructing lung)and reduce the inflammatory response without increasing the incidence of adverse reactions in elderly patients with acute exacerbation of COPD(syndrome of turbid phlegm obstructing lung)and pulmonary infection while conventional western medicine treatment.
作者
舒欣
SHU Xin(Jiangxi Integrated Traditional Chinese and Western Medicine Hospital,Nanchang Jiangxi 330003,China)
出处
《药品评价》
CAS
2021年第17期1064-1068,共5页
Drug Evaluation
关键词
肺疾病
慢性阻塞性
小青龙汤
六君子汤
肺部感染
Pulmonary disease,chronic obstructive
Xiaoqinglong decoction
Liujunzi decoction
Lung infection
