摘要
目的:系统评价臭氧自体血回输疗法治疗带状疱疹后神经痛的疗效。方法:计算机检索PubMed、Embase、The Cochrane Library、中国生物医学文献数据库(CBM)等数据库,使用Cochrane风险偏倚评价工具评价纳入研究的偏倚风险,采用RevMan 5.3软件进行Meta分析。结果:共纳入7个研究497例患者,与常规药物治疗相比,臭氧自体血回输疗法联合常规药物治疗能降低带状疱疹后神经痛患者疼痛视觉模拟评分(VAS评分)[MD=-2.44,95%CI(-3.35,-1.54),P<0.05]和简明疼痛评估量表(BPI)指数:情绪[MD=-2.09,95%CI(-3.07,-1.11),P<0.05]、睡眠[MD=-2.28,95%CI(-3.16,-1.40),P<0.05]、饮食[MD=-2.40,95%CI(-2.72,-2.08),P<0.05]、日常生活[MD=-1.94,95%CI(-2.52,-1.36),P<0.05];与常规药物治疗联合其他疗法相比,臭氧自体血回输疗法能降低带状疱疹后神经痛患者VAS评分[MD=-0.88,95%CI(-1.22,-0.54),P<0.05]。结论:现有证据表明,与常规药物治疗联合神经阻滞治疗相比,臭氧自体血回输疗法联合常规药物治疗与神经阻滞治疗可改善带状疱疹后神经痛患者的疼痛;与单纯常规药物治疗组相比,臭氧自体血回输疗法联合常规药物治疗对带状疱疹后神经痛患者可改善患者疼痛、情绪、睡眠、饮食、日常生活。
Objective:To systematically evaluate the effect of ozone autologous blood infusion therapy for the treatment of post-herpetic neuralgia.Methods:PubMed,Embase,The Cochrane Library,CBM and other databases were searched.Cochrane risk bias evaluation tool was used to evaluate the risk of bias in the included literature,and RevMan 5.3 software was used for Meta-analysis.Results:A total of 497 patients from 7 studies were included.Compared with conventional drug therapy,ozone autologous blood infusion therapy combined with conventional drug therapy can significantly reduce the VAS score of the patients with post-herpetic neuralgia[MD=-2.44,95%CI(-3.35,-1.54),P<0.05]and their brief pain inventory(BPI)index:emotion[MD=-2.09,95%CI(-3.07,-1.11),P<0.05],sleep[MD=-2.28,95%CI(-3.16,-1.40),P<0.05],diet[MD=-2.40,95%CI(-2.72,-2.08),P<0.05],daily life[MD=-1.94,95%CI(-2.52,-1.36),P<0.05].Compared with conventional drug therapy combined with other therapies,ozone autologous blood transfusion therapy can also significantly reduce the VAS score of patients with post-herpetic neuralgia[MD=-0.88,95%CI(-1.22,-0.54),P<0.05].Conclusion:Existing evidence shows that ozone autologous blood infusion therapy combined with conventional drug therapy and nerve block therapy improves pain in patients with pos-therpetic neuralgia compared with conventional drug therapy and nerve block therapy combined.Ozone autologous blood infusion therapy combined with conventional drug therapy improves pain,emotion,sleep,diet,and daily life in patients with pos-therpetic neuralgia compared with conventional drug therapy.
作者
陈楠
冯鹿方
李美萱
白飞
杨克虎
杜威萍
李秀霞
CHEN Nan;FENG Lufang;LI Meixuan;BAI Fei;YANG Kehu;DU Weiping;LI Xiuxia(Health Technology Assessment Center,Evidence-Based Social Science Research Center,School of Public Health,Lanzhou University,Gansu Lanzhou 730000,China;Evidence Based Medicine Center,School of Basic Medical Sciences,Lanzhou University,Gansu Lanzhou 730000,China;Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province,Gansu Lanzhou 730000,China;National Center for Medical Service Administration,National Health Commission of the People′s Republic of China,Beijing 100086,China;Department of Dermatology,Wuwei People′s Hospital,Gansu Wuwei 733000,China)
出处
《中国医药导刊》
2021年第9期641-646,共6页
Chinese Journal of Medicinal Guide
基金
中央高校基本科研业务费专项资金(项目编号:lzujbky-2021-kb22,项目名称:中药基因研究现状及其数据库的研发)
甘肃省循证医学与临床转化重点实验室开放基金(项目编号:GSEBMKT-2021wsjspg01,项目名称:卫生技术评估专项)。
