摘要
目的:探讨术前乙型肝炎病毒(hepatitis B virus,HBV)感染状态与肝癌切除术后预后的关系。方法:选择2014年7月至2015年6月复旦大学附属中山医院收治的行根治性切除的肝细胞癌患者910例,收集术前乙肝两对半和HBV-DNA的结果,结合临床病理信息和随访资料,阐明肝癌患者乙肝感染状态和其对患者预后的影响。结果:95.1%的肝癌手术患者存在乙型肝炎病毒感染,其中以“小三阳”者最为多见,占54.2%。HBV-DNA的阳性患者术后无瘤生存率及总生存率显著低于阴性患者(P<0.05)。HBV-DNA阳性组和阴性组的肝硬化程度、甲胎蛋白(alpha-fetoprotein,AFP)水平、肿瘤大小以及血管侵犯差异均有统计学意义(P<0.001)。结论:完善乙肝血清学标志物的检测,有利于肝癌的防治以及改善患者预后。
Objective:Hepatitis B virus(HBV)infection is a risk factor for primary liver cancer.This article aims to explore the relationship between the preoperative HBV infection status and the prognosis after liver cancer resection.Methods:Totally,910 patients with hepatocellular carcinoma undergoing radical resection were randomly selected.Clinicopathological information,preoperative hepatitis B marker serological examination,and follow-up data were used to analyze the relationship between preoperative hepatitis B infection status and patient prognosis.Results:95.1%of patients undergoing surgery for liver cancer had hepatitis B virus infection,of whom the"small three positives"were the most common,accounting for 57.0%.The postoperative tumor-free survival rate and overall survival rate of HBV-DNA-positive patients were significantly lower than those of negative patients(P<0.05).HBV-DNA was positively correlated with liver cirrhosis,alpha-fetoprotein level,tumor size,and vascular invasion(P<0.001).Conclusions:Enhancing the detection of hepatitis B serum markers is beneficial for the prevention and treatment of liver cancer and could improve patient prognosis.
作者
桑瑞瑞
杨春晨
沈早卓
贺轶锋
黄晓武
施杰毅
周蓉
SANG Rui-rui;YANG Chun-chen;SHEN Zao-zhuo;HE Yi-feng;HUANG Xiao-wu;SHI Jie-yi;ZHOU Rong(Department of Transfusion, Zhongshan Hospital, Fudan University, Shanghai 200032, China;Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200032, China)
出处
《中国临床医学》
2021年第5期838-841,共4页
Chinese Journal of Clinical Medicine
基金
国家自然科学基金(81872321).
关键词
乙型肝炎
乙肝两对半
HBV-DNA
原发性肝癌
hepatitis B
immunological examinations of hepatitis B
HBV-DNA
primary liver cancer
