摘要
The evolution of coronaviruses,such as SARS-CoV-2,makes broad-spectrum coronavirus preventional or therapeutical strategies highly sought after.Here we report a human angiotensin-converting enzyme 2(ACE2)-targeting monoclonal antibody,3E8,blocked the S1-subunits and pseudo-typed virus constructs from multiple coronaviruses including SARS-CoV-2,SARS-CoV-2 mutant variants(SARS-CoV-2-D614G,B.1.1.7,B.1.351,B.1.617.1,and P.1).
基金
This work was supported by the China National Major Scientific and Technological Special Project for"Significant New Drugs Innovation and Development"(2019ZX09732002-006)
the Strategic Priority Research Program of the Chinese Academy of Sciences(CAS)(XDA12020223 and XDA12020330)
the National Natural Science Foundation of China(81872785,81673347,31971123,32022037,81920108015,and 31930059)
Shanghai Municipal Commission of Science and Technology of China(17431904400 and 19YF1457400)
Institutes for Drug Discovery and Development,Chinese Academy of Sciences(CASIMM0120202008 and CASIMM0120202007)
the National Key R&D Program(2020YFA0509303)
Major Scientific and Technological Special Project of Zhongshan City(191022172638719 and 210205143867019)
the Key R&D Program of Zhejiang Province(2020C04001)
the SARS-CoV-2 emergency project of the Science and Technology Department of Zhejiang Province(2020C03129)
the Leading Innovative and Entrepreneur Team Introduction Program of Hangzhou,Westlake Education Foundation and Tencent Foundation.
