摘要
目的:探讨BRAF V600E突变判断甲状腺乳头状癌(papillary carcinoma of thyroid,PTC)侵袭性的价值及与超声特征的相关性。方法:选取经术后病理学检查证实,术前行超声引导下细针抽吸细胞学检查(fine-needle aspiration cytology,FNAC)及BRAF V600E检测PTC患者174例,分为突变组(151例)与无突变组(23例),比较各临床病理学及超声特征的组间差异,单因素分析与BRAF V600E突变的相关性,二元logistic回归分析筛选出与BRAF V600E突变密切相关危险因素。结果:组间比较BRAF V600E突变与各临床病理学特征差异均无统计学意义(P>0.05);与部分超声特征(结节位置、最大径、钙化、后方衰减)差异有统计学意义(P<0.05);甲状腺癌结节钙化及位置是与BRAF V600E突变密切相关的独立危险因素(P<0.05),无钙化或贴近前包膜PTC结节更易发生BRAF V600E突变。结论:BRAF V600E突变与PTC侵袭性特征无明显相关性,与钙化及位置密切相关。当可疑PTC结节无钙化或贴近前包膜时发生BRAF V600E突变概率大。
Objective:To evaluate the value of BRAF V600E mutation in determining the invasiveness of papillary carcinoma of thyroid(PTC)and its related influencing factors.Methods:A total of 174 PTC patients who underwent ultrasound guided fineneedle aspiration cytology(FNAC)and BRAF V600E mutation detection before surgery were selected.All PTC patients were divided into mutation group 151 cases and no mutation group of 23 cases.The clinical pathological features and the ultrasonic characteristics between the two groups were compared,and single factor analyzed the correlation between observational indexes and BRAF V600E mutation,binary logistic regression analysis screened out risk factors closely related to BRAF V600E mutation.Results:There was no statistical difference in BRAF V600E mutation and clinicopathological features between the two groups(P>0.05),and there was a statistical difference in some ultrasonic features(nodule position,maximum diameter,calcification,and posterior attenuation)between them(P<0.05).Only the calcification and location of cancer nodules were closely related to BRAF V600E(P<0.05).BRAF V600E mutations were more likely to occur in the PTC nodules which were close to the anterior capsule and without calcification.Conclusion:BRAF V600E mutation has no obvious correlation with PTC invasive characteristics,and it is closely related to calcification and location in ultrasonic features.When the suspected PTC nodule has no calcification or is close to the anterior capsule,BRAF V600E mutation is likely more freguent.
作者
赵美丽
张文婷
常隽
陈松旺
邵国强
ZHAO Meili;ZHANG Wenting;CHANG Jun;CHEN Songwang;SHAO Guoqiang(Department of Functional Examination,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,Jiangsu Province,China;Department of Nuclear Medicine,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,Jiangsu Province,China)
出处
《肿瘤影像学》
2021年第5期376-381,共6页
Oncoradiology
基金
江苏省“六个一工程”拔尖人才项目(LGY2019005)。
