摘要
通过系统梳理一贯煎的中医古籍及现代临床文献,对其出处、组成、基原、炮制要求、剂量、制法用法、功能主治、方义衍变等历史沿革进行考证,明晰一贯煎的历史沿革和临床应用研究概况。在充分考虑经典名方制剂开发实际需求及现代临床实践使用习惯的基础上,提出可行的开发建议。清朝钱敏捷《医方絜度》所载一贯煎由6味药物组成,其组方药物基原及药用部位选用与2020年版《中华人民共和国药典》(简称《中国药典》)收载品种保持一致,所选药物皆为生品,并参照2020年版《中国药典》收载方法炮制。该方药物参考剂量以《医方絜度》所载为准,按照一钱相当于今3.73 g折算,北沙参、麦冬、当归各5.60 g,枸杞子、生地黄各11.19 g,川楝子7.46 g;水煎服;古医籍记载一贯煎功效为滋阴疏肝,主治肝肾阴虚,肝气郁滞证,证见胸脘胁痛,吞酸吐苦,咽干口燥,舌红少津,脉细弱或虚弦及疝气瘕聚。本研究明确了一贯煎的出处与组成、药物基原、药物炮制、剂量用法、功能主治与方义衍变及现代临床应用,可为该经典名方的开发与应用提供文献参考依据。
By systematically sorting out the ancient medical books and modern clinical literature of Yiguanjian,the historical evolution of this formula,including its source,composition,origin,processing,dosage,preparation and usage,functions and indications,evolution of prescription meaning,is textual so as to clarify the historical evolution and clinical application of Yiguanjian. On the basis of fully considering the actual demand of development of famous classical formula preparation and the usage habit of modern clinical practice,the feasible development suggestions were put forward. Yiguanjian is composed of six herbs,which is derived from Yifang Jiedu(《医方絜度》). It is an ancient book of traditional Chinese medicine edited by QIAN Min-jie in Qing dynasty. The original medicinal plants and medicinal parts of the formula were basically the same as those recorded in the 2020 edition of Chinese Pharmacopoeia. The raw products should be selected for decoction pieces and processed according to the methods recorded in the 2020 edition of Chinese Pharmacopoeia. The reference dose of the medicine in this formula is set out in Yifang Jiedu. According to dosage of one Qian( 钱 )=3.73 g,the dosages of Glehniae Radix,Ophiopogonis Radix and Angelicae Sinensis Radix were 5.60 g,the dosages of Lycii Fructus and Rehmanniae Radix were 11.19 g,the dosage of Toosendan Fructus was 7.46 g.These decoction pieces were boiled and warm decoction was taken. According to ancient medical records,the formula always has the effect of nourishing Yin and relieving Qi of liver. It is used to treat syndrome of stagnation of liver-Qi and deficiency of liver-Yin and kidney-Yin,which can be seen with pain in chest,stomach and flank,acerbity and vomiting,dry throat and mouth,red tongue,weak pulse or deficiency of string and hernia. Here,the source, processing and others of Yiguanjian were clarified, providing a literature reference for the development and application of this famous classical formula.
作者
梁悦
王长虹
程雪梅
徐莹
林超颖
李荣胜
都广礼
潘一峰
刘平
刘伟
LIANG Yue;WANG Chang-hong;CHENG Xue-mei;XU Ying;LIN Chao-ying;LI Rong-sheng;DU Guang-li;PAN Yi-feng;LIU Ping;LIU Wei(Institute of Liver Diseases,Key Laboratory of Liver and Kidney Diseases,Ministry of Education,Shanghai Key Laboratory of Traditional Chinese Clinical Medicine,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine(TCM),Shanghai 201203,China;Institute of Chinese Materia Medica,School of Basic Medical Sciences,Shanghai University of TCM,Shanghai 201203,China;Shanghai Huanghai Pharmaceutical Co.Ltd.,Shanghai 200942,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第22期15-22,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金重点项目(82130120)
国家自然科学基金项目(82004162,81703681)
上海市科技创新行动计划项目(20S21902600)
上海市青年科技英才扬帆计划项目(20YF14495000)
中国博士后基金面上项目(2020M681367)。
关键词
一贯煎
处方考证
基原
炮制
经典名方
功能主治
临床应用
Yiguanjian
prescription textual research
origin
processing
famous classical formulas
functions and indications
clinical application
