摘要
抗肿瘤分子靶向药物因其靶向性强、安全性高、毒副作用小等优点已广泛用于恶性肿瘤的治疗。然而,分子靶向药物相关皮炎不仅影响了患者的生活质量和用药依从性,也影响其临床疗效的发挥。目前关于皮炎的发病机制尚不清楚,也缺乏有效的治疗手段。笔者从皮炎概况、治疗现状、发病机制、动物模型的常见造模方法,以及观察指标等5个方面进行综述,以期为分子靶向药物合理用药及不良反应研究提供科学依据。
Antineoplastic molecular targeting drugs have been widely used in the treatment of malignant tumors because of their strong targeting,high safety and low side effects.However,molecular targeted drug-associated dermatitis not only affects the quality of life and drug compliance of patients,but also affects its clinical efficacy.At present,the pathogenesis of dermatitis is not clear,and there is a lack of effective treatment.This article reviews the general situation,treatment status,pathogenesis,common modeling methods of animal models and observation indicators of dermatitis,in order to provide scientific basis for the rational use of molecular targeted drugs and adverse reactions.
作者
王致红
张铭予
李春雨
李国辉
WANG Zhi-hong;ZHANG Ming-yu;LI Chun-yu;LI Guo-hui(National Cancer Center,National Clinical Research Center for Cancer,Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2021年第19期1551-1556,共6页
Chinese Pharmaceutical Journal
基金
中国癌症基金会北京希望马拉松专项基金资助(LC2020A28)。
