摘要
目的探讨汉族人群中代谢综合征(Mets)及其各组分(体质量超标和(或)肥胖、高糖血症、高血压、血脂紊乱)与颅内动脉粥样硬化性狭窄(ICAS)的相关性。方法纳入2014年1月—2018年6月在青岛市市立医院神经内科住院和健康查体中心体检的汉族人1 009例,应用2004年中华医学会糖尿病学分会公布的Mets标准诊断Mets,采用华法林-阿司匹林治疗症状性颅内动脉狭窄的随机对照研究(WASID)方法测定ICAS程度。根据是否存在ICAS分为ICAS组190例和非狭窄组819例。采用多因素Logistic回归分析Mets及其组分与ICAS的相关性;不同Mets组分数量者ICAS发生率的比较采用Cochran-Armitage趋势检验。结果总人群中Mets与ICAS显著相关(OR=1.59,95%CI=1.15~2.20,P=0.005);随着Mets组分数量的增多,ICAS发生率增高(χ^(2)=8.84,P<0.01);Mets组分中的高糖血症与ICAS显著相关(OR=1.43,95%CI=1.03~1.98,P=0.032)。亚组分析提示,女性(OR=2.17,95%CI=1.27~3.70,P=0.005)和老年(OR=1.77,95%CI=1.22~2.57,P=0.002)人群Mets与ICAS显著相关,且随着Mets组分数量的增多ICAS发生率增高(χ^(2)=11.12、12.28,P<0.001)。此外,女性高糖血症与ICAS显著相关(OR=1.86,95%CI=1.06~3.27,P=0.031),老年人高血压与ICAS显著相关(OR=2.41,95%CI=1.17~4.97,P=0.017)。结论 Mets与ICAS显著相关,ICAS的发生率随着Mets组分数量增多而增高,Mets组分中的高糖血症与ICAS显著相关。性别和年龄对Mets与ICAS的关系有影响。
Objective To investigate the association of metabolic syndrome(Mets) and its components(overweight and/or obesity, hyperglycemia, hypertension, dyslipidemia) with intracranial arterial stenosis(ICAS) in the Chinese Han population.Methods A total of 1 009 Chinese Han individuals who were hospitalized in Department of Neurology or underwent physical examination in Health Examination Center, Qingdao Municipal Hospital, from January 2014 to June 2018 were enrolled. Mets was diagnosed based on the diagnostic criteria for Mets published by Chinese Diabetes Society of Chinese Medical Association in 2004, and the severity of ICAS was measured by the method based on the Warfarin-Aspirin Symptomatic Intracranial Disease study. Accor-ding to the presence or absence of ICAS, the individuals were divided into ICAS group with 190 individuals and non-stenosis group with 819 individuals. A multivariate Logistic regression analysis was used to investigate the association of Mets and its components with ICAS, and the Cochran-Armitage trend test was used to compare the incidence rate of ICAS between individuals with different numbers of Mets components. Results In the overall population, Mets was significantly associated with ICAS(OR=1.59,95%CI=1.15-2.20,P=0.005), and the incidence rate of ICAS increased with the increase in the number of Mets components(χ^(2)=8.84,P<0.01). Among the Mets components, hyperglycemia was significantly associated with ICAS(OR=1.43,95%CI=1.03-1.98,P=0.032). The subgroup analysis showed that Mets was significantly associated with ICAS in women(OR=2.17,95%CI=1.27-3.70,P=0.005) and the elderly(OR=1.77,95%CI=1.22-2.57,P=0.002), and the incidence rate of ICAS increased with the increase in the number of Mets components in women and the elderly(χ^(2)=11.12, 12.28;P<0.001). In addition, hyperglycemia was significantly associated with ICAS in women(OR=1.86,95%CI=1.06-3.27,P=0.031), and hypertension was significantly associated with ICAS in the elderly(OR=2.41,95%CI=1.17-4.97,P=0.017). Conclusion Mets is significantly asso-ciated with ICAS, and the incidence rate of ICAS increases with the increase in the number of Mets components. Among Mets components, hyperglycemia is significantly associated with ICAS. Sex and age have an impact on the association between Mets and ICAS.
作者
郭春燕
万秀明
谭兰
GUO Chunyan;WAN Xiuming;TAN Lan(Department of Neurology,Qingdao Municipal Hospital,Qingdao University,Qingdao 266011,China)
出处
《青岛大学学报（医学版）》
2021年第5期712-716,共5页
Journal of Qingdao University(Medical Sciences)
基金
山东省泰山学者基金项目(ts201511109)。
关键词
代谢综合征
颅内动脉硬化
危险因素
数据相关性
metabolic syndrome
intracranial arterio-sclerosis
risk factor
correlation of data
