摘要
目的:观察在常规疗法基础上加用穴位贴敷联合针刺治疗瘀血内阻型缺血性脑卒中后失眠的临床疗效以及对血浆多巴胺(DA)含量的影响。方法:纳入88例瘀血内阻型缺血性脑卒中并发失眠的患者,按随机数字表法分为对照组和观察组各44例。2组均予常规治疗方案与右佐匹克隆片治疗,观察组加予助阳通气方穴位贴敷和针刺疗法治疗。2组均治疗4周。比较2组患者治疗前1 d与治疗4周后的匹兹堡睡眠质量指数(PSQI)评分、多导睡眠检测结果、血浆DA含量以及治疗4周后的临床疗效。结果:治疗4周后,观察组临床疗效总有效率高于对照组(P<0.05)。2组PSQI入睡时间、睡眠效率、睡眠时间、睡眠障碍及日间功能障碍评分均较治疗前降低(P<0.01),观察组5项评分均低于对照组(P<0.01)。2组睡眠总时间与治疗前相比均增加,睡眠潜伏期、觉醒次数均较治疗前缩短或减少(P<0.01),观察组睡眠总时间多于对照组,睡眠潜伏期、觉醒次数短于或少于对照组(P<0.01)。2组血浆DA含量均较治疗前降低(P<0.01),观察组血浆DA含量低于对照组(P<0.01)。结论:在常规疗法基础上加用穴位贴敷联合针刺治疗瘀血内阻型缺血性脑卒中后失眠患者,在改善失眠、提高睡眠质量方面疗效显著,下调DA含量可能与其疗效有关。
Objective: To observe the clinical effect of point application and acupuncture based on routine therapy for insomnia after ischemic stroke of internal obstruction of blood stasis type and its effect on contents of dopamine(DA) in plasma. Methods:A total of 88 cases of patients with ischemic stroke complicated with insomnia were included and divided into the control group and the observation group according to the random number table method,44 cases in each group. Both groups were given routine treatment plan and treated with eszopiclone tablets,and the observation group was additionally treated with point application with Zhuyang Tongqi prescription and acupuncture therapy. Both groups were treated for four weeks. The scores of Pittsburg Sleep Quality Index(PSQI),the results of polysomnography and the contents of plasma DA in one day before treatment and after four-week treatment respectively as well as the clinical effect after four-week treatment in the two groups were compared. Results:After four-week treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05). The PSQI scores of fall asleep time, sleep efficiency, sleep disorders and daytime dysfunction in the two groups were decreased when compared with those in one day before treatment(P<0.01),and the above five scores in the observation group was lower than that in the control group(P<0.01). The total sleep time in the two groups was increased when compared with that in one day before treatment,and the sleep latency and the number of wakefulness were shortened or decreased when compared with those before treatment(P<0.01). The total sleep time in the observation group was longer than that in the control group,and the sleep latency and the number of wakefulness were shorter or fewer than those in the control group(P<0.01). The contents of plasma DA in the two groups were decreased when compared with those before treatment(P<0.01),and the content in the observation group was lower than that in the control group(P<0.01). Conclusion: Based on routine therapy, the additional application of point application combined with acupuncture for patients with insomnia after ischemic stroke of internal obstruction of blood stasis type has significant curative effect in improving insomnia and sleep quality,and the down-regulation of contents of DA may be related to its curative effect.
作者
曾芳芳
余丽红
王丽君
ZENG Fangfang;YU Lihong;WANG Lijun
出处
《新中医》
CAS
2021年第20期156-160,共5页
New Chinese Medicine
关键词
缺血性脑卒中
失眠
瘀血内阻型
穴位贴敷
针刺
睡眠质量
多巴胺
Ischemic stroke
Insomnia
Internal obstruction of blood stasis type
Point application
Acupuncture
Sleep quality
Dopamine
