摘要
目的探讨超声软指标在孕早期胎儿染色体异常筛查中的临床价值。方法选择在我院行常规产前筛查的孕早期孕妇1945例,均行超声软指标[胎儿鼻骨(NB)、颈项透明层厚度(NT)检查]和母体血清学检查。以羊水穿刺染色体核型分析或低风险孕妇进行产后随访为金标准,分析各方式检查价值。结果1945例孕早期孕妇中共检出胎儿染色体异常40例(2.06%),其中18-三体综合征7例(0.36%),21-三体综合征19例(0.98%),45X 4例(0.21%),13-三体综合征5例(0.26%),染色体片段异常2例(0.10%),三倍体3例(0.15%);NT异常126例(6.48%),NT正常1819例(93.52%);NB缺失12例(0.62%),NB正常1932例(99.33%),羊水穿刺显示,胎儿染色体异常28例(1.44%);血清学筛查高风险孕妇111例(5.71%),经羊水穿刺显示,胎儿染色体异常31例(1.59%);超声软指标联合血清学检查对胎儿染色体异常检出率高于超声软指标、血清学单一检查,差异具有统计学意义(P<0.05);超声软指标、血清学对胎儿染色体异常检出率相比,差异无统计学意义(P>0.05)。结论超声软指标能够有效检出孕早期胎儿染色体异常,联合血清学检查能够提高胎儿染色体异常检出率,提高出生人口质量。
Objective To explore the clinical value of ultrasound soft index in screening fetal chromosomal abnormalities in early pregnancy.Methods 1945 pregnant women in the first trimester of pregnancy who underwent routine prenatal screening in our hospital were selected.All of them underwent ultrasound soft indicators[(fetal nasal bone(NB)),neck translucency thickness(NT)]and maternal serological examination.Amniocentesis chromosome karyotype analysis or postpartum follow-up of low-risk pregnant women were used as gold standard to analyze the value of each method.Results A total of 40 cases of fetal chromosomal abnormalities(2.06%)were detected in 1945 pregnant women in the first trimester,including 7 cases of 18 trisomy syndrome(0.36%),19 cases of 21 trisomy syndrome(0.98%),4 cases of 45x(0.21%),5 cases of 13 trisomy syndrome(0.26%),2 cases of chromosome segment abnormality(0.10%),3 cases of triploidy(0.15%);126 cases of NT abnormalities(6.48%),1819 cases of normal NT(93.52%);12 cases of NB deletion(0.62%),1932 cases of normal NB(99.33%),amniocentesis showed 28 cases(1.44%)of fetal chromosomal abnormalities;111 cases(5.71%)of high-risk pregnant women were screened by serology,Amniocentesis showed 31 cases(1.59%)of fetal chromosomal abnormalities;the detection rate of fetal chromosomal abnormalities by ultrasound soft index combined with serological examination was higher than that by ultrasound soft index and serological single examination,the difference was statistically significant(P<0.05);There was no significant difference in the detection rate of fetal chromosomal abnormalities between ultrasound soft index and serology(P>0.05).Conclusion Ultrasound soft index can effectively detect fetal chromosomal abnormalities in early pregnancy,which combined with serological examination can improve the detection rate of fetal chromosomal abnormalities and improve the quality of the birth population.
作者
刘倩倩
Liu Qianqian(Nanyang Second People's Hospital,Prenatal Screening Center,Nanyang 473012,China)
出处
《哈尔滨医药》
2021年第5期36-38,共3页
Harbin Medical Journal
关键词
胎儿染色体异常
超声软指标
筛查
颈项透明层厚度
Fetal chromosomal abnormalities
Ultrasound soft index
Screening
Nuchal translucency thickness
