摘要
目的以心肌梗死者为研究对象,探究氯吡格雷联合胺碘酮的治疗效果。方法方便选取2019年1月—2020年7月该院接收的88例心肌梗死患者,以数字号形式分设组别,即对照组(n=44)、观察组(n=44)。氯吡格雷单纯治疗为对照组,氯吡格雷联合胺碘酮治疗为观察组。以治疗疗效、血清炎症因子、凝血功能水平为判定指标,对不同药物取得效果进行分析。结果总有效率统计,对照组、观察组分别为81.82%、95.45%,前者低于后者,差异有统计学意义(χ^(2)=4.062,P<0.05)。在比较血清炎症因子水平中,治疗后,观察组较对照组数据结果更低,差异有统计学意义(t=8.706、6.344、4.404,P<0.05)。在比较凝血功能水平中,治疗后,观察组较对照组数据结果更高,差异有统计学意义(t=5.052、14.423、4.761,P<0.05)。在比较心功能指标中,治疗后,观察组较对照组左心室收缩末期内径、左心室舒张末期内径数据更低,左心室射血分数数据结果更高,差异有统计学意义(t=6.923、5.010、5.037,P<0.05)。结论对心肌梗死患者予以氯吡格雷和胺碘酮共同用药治疗,能取得较好治疗效果,有助于患者病情缓解,凝血功能和心功能改善,同时还能对血清炎性因子进行有效抑制,加快病情恢复。
Objective Taking the patients with myocardial infarction as the research object,the treatment effect of clopidogrel combined with amiodarone was explored.Methods The 88 patients with myocardial infarction received by the hospital from January 2019 to July 2020 were conveniently selected and groups were divided into groups in the form of numbers,namely the control group(n=44)and the observation group(n=44).The patients in the control group were selected as clopidogrel alone,and the patients in the observation group were treated with clopidogrel combined with amiodarone.The therapeutic effect,serum inflammatory factors,and blood coagulation function level are used as indicators to analyze the effects of different drugs.Results The total effective rate statistics,the control group and the observation group were 81.82%,95.45%,the former is lower than the latter,the difference is statistically significant(χ^(2)=4.062,P<0.05).In the comparison of serum inflammatory factor levels,after treatment,the data score of the observation group was lower than that of the control group,and the difference was statistically significant(t=8.706,6.344,4.404,P<0.05).In comparing the level of coagulation function,after treatment,the results of the observation group were higher than those in the control group,and the difference was statistically significant(t=5.052,14.423,4.761,P<0.05).In the comparison of cardiac function indicators,after treatment,compared with the control group,the observation group had lower left ventricular end systolic diameter and left ventricular end diastolic diameter data scores,and the left ventricular ejection fraction data results were higher,and the difference was statistically significant(t=6.923,5.010,5.037,P<0.05).Conclusion The combination of clopidogrel and amiodarone in the treatment of myocardial infarction patients can achieve better therapeutic effect,contribute to the remission of the patient's condition,improve the coagulation function and cardiac function,but also can effectively inhibit the serum inflammatory factors,speed up the recovery of the condition.
作者
周守荣
ZHOU Shourong(Department of Internal Medicine,Fifth People's Hospital of Dongying City,Dongying,Shandong Province,257500China)
出处
《中外医疗》
2021年第26期77-80,共4页
China & Foreign Medical Treatment
关键词
血清炎症因子
氯吡格雷
胺碘酮
心肌梗死
凝血功能
Serum inflammatory factors
Clopidogrel
Amiodarone
Myocardial infarction
Coagulation function
