摘要
目的探究针对罹患胃炎合并胃溃疡的患者,采用奥美拉唑+阿莫西林联合治疗的临床效果分析。方法研究抽取该院2018年1月—2020年1月的110例胃炎合并胃溃疡患者,遵照1∶1的分配比例划分为两组,即单一组(n=55,奥美拉唑治疗)与联合组(n=55,奥美拉唑+阿莫西林治疗),就两组的炎性因子指标、胃泌素族指标、免疫功能指标、临床疗效及不良反应发生率展开对比分析。结果联合组治疗后的CRP、TNF-α、IL-6各项炎性因子指标与单一组相比,均明显处于更低水平,差异有统计学意义(t=18.267、6.203、16.593,P<0.001);联合组治疗后的CCK、GAS指标相较单一组明显大幅降低,差异有统计学意义(t=6.570、12.360,P<0.001),MTL指标则明显大幅升高,差异有统计学意义(t=6.850,P<0.001);联合组治疗后的CD4^(+)、CD4^(+)/CD8^(+)免疫功能指标明显高于单一组,差异有统计学意义(t=3.807、2.834,P<0.05),CD8^(+)指标则明显低于单一组,差异有统计学意义(t=5.866,P<0.001);对比两组总有效率的数据,联合组明显拥有更高水准,差异有统计学意义(χ^(2)=6.253,P=0.012);联合组7.27%(4/55)的并发症发生率优于单一组,差异有统计学意义(χ^(2)=5.636,P=0.018)。结论胃炎合并胃溃疡患者经由奥美拉唑+阿莫西林的联合治疗,其炎性因子指标、胃泌素族指标等均得以明显改善,身体免疫力得以大幅提高,药效显著的同时具备更强的安全性,值得临床借鉴并大力推广。
Objective To explore the clinical effects of omeprazole+amoxicillin combined treatment for patients suffering from gastritis with gastric ulcer.Methods The study selected 110 patients with gastritis and gastric ulcer from the hospital from January 2018 to January 2020,and divided them into two groups according to a 1:1 distribution ratio,namely a single group(n=55,omeprazole treatment)and a combined group Group(n=55,omeprazole+amoxicillin treatment),the two groups of inflammatory factor indicators,gastrin family indicators,immune function indicators,clinical efficacy and incidence of adverse reactions were compared and analyzed.Results The inflammatory factors of CRP,TNF-αand IL-6 in the combined group were significantly lower than the single group after treatment,and the difference was statistically significant(t=18.267,6.203,16.593,P<0.001),the CCK and GAS indexes of the combined group were significantly lower than the single group after treatment,the difference was statistically significant(t=6.570,12.360,P<0.001),the MTL index was significantly increased,and the difference was statistically significant(t=6.850,P<0.001);the CD4^(+),CD4^(+)/CD8^(+)immune function indexes of the combined group after treatment were significantly higher than those of the single group,the difference was statistically significant(t=3.807,2.834,P<0.05),and the CD8^(+)index was significantly lower than that in the single group,the difference was statistically significant(t=5.866,P<0.001);comparing the total effective rate data of the two groups,the combined group obviously had a higher level,the difference was statistically significant(χ^(2)=6.253,P=0.012);the complication rate of 7.27%(4/55)in the combined group was much better than that of the single group,and the difference was statistically significant(χ^(2)=5.636,P=0.018).Conclusion After the combined treatment of omeprazole and amoxicillin for gastritis patients with gastric ulcer,the inflammatory factors and gastrin group indexes were significantly improved,and the body immunity was greatly improved.Besides the significant efficacy,it had stronger safety,which was worthy of clinical reference and promotion.
作者
常文杰
CHANG Wenjie(Department of Gastroenterology,Jining Women's and Children's Hospital,Jining,Shandong Province,272000 China)
出处
《系统医学》
2021年第17期15-18,26,共5页
Systems Medicine
基金
阿莫西林与奥美拉唑联合治疗胃炎并胃溃疡的临床观察(KJCX9437)。
关键词
胃炎合并胃溃疡
阿莫西林
奥美拉唑
炎性因子
胃泌素
免疫功能
临床疗效
不良反应
Gastritis with gastric ulcer
Amoxicillin
Omeprazole
Inflammatory factors
Gastrin
Immune function
Clinical efficacy
Adverse reactions
