摘要
目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者血清C反应蛋白(CRP)浓度与肺功能水平的相关性。方法选取诊断为AECOPD患者82例及健康体检者22例,以健康体检者作对照组,AECOPD患者按肺功能检查结果分为Ⅰ级组18例、Ⅱ级组22例、Ⅲ级组23例、Ⅳ级组19例,比较不同组别患者的肺功能、血清CRP水平差异。结果对照组血清CRP水平明显低于AECOPD各组,差异均有统计学意义(P<0.01)。对照组第一秒用力呼气容积占预计值百分比(FEV1%pred)明显高于Ⅱ级组、Ⅲ级组、Ⅳ级组,差异均有统计学意义(P<0.01);对照组肺功能的一秒率(FEV1/FVC)明显高于Ⅱ级组、Ⅲ级组、Ⅳ级组,差异均有统计学意义(P<0.01)。AECOPD患者血清CRP与FEV1%pred呈负相关(r=-0.829,P<0.01);AECOPD患者血清CRP与FEV1/FVC呈负相关(r=-0.693,P<0.01)。结论 AECOPD患者血清CRP浓度的增高与肺功能损伤程度相关,可以作为评估AECOPD患者肺功能损伤程度的参考指标。
Objective To investigate the correlation between serum C-reactive protein(CRP)concentration and pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods A total of 82 patients with AECOPD and 22 healthy people were selected. Taking the healthy persons as the control group,patients with AECOPD were divided into 18 patients in grade Ⅰ group,22 patients in grade Ⅱ group,23 patients in grade Ⅲ group and 19 patients in grade Ⅳ group according to the results of pulmonary function examination. The differences of pulmonary function and serum CRP levels in different groups were compared. Results The level of serum CRP in control group was significantly lower than that in AECOPD each group,and the differences were statistically significant(P<0.01);the percentage of forced expiratory volume in the predicted value in the first second(FEV_(1)% pred)in the control group was significantly higher than that in grade Ⅱ group,grade Ⅲ group and grade Ⅳ group,and the differences were statistically significant(P<0.01);the one second rate of pulmonary function(FEV_(1)/FVC)in the control group was significantly higher than that in grade Ⅱ group,grade Ⅲ group and grade Ⅳ group,and the differences were statistically significant(P<0.01). There was a negative correlation between serum CRP and FEV_(1)%pred in patients with AECOPD(r=-0.829,P<0.01);there was a negative correlation between serum CRP and FEV_(1)/FVC in patients with AECOPD(r =-0.693,P <0.01). Conclusion The increase of serum CRP concentration in patients with AECOPD was related to the degree of pulmonary function injury,which could be used as a reference index to evaluate the degree of pulmonary function injury in patients with AECOPD.
作者
吴健广
刘圆圆
WU Jian-guang;LIU Yuan-yuan(Department of First Internal Medicine,Traditional Chinese Medicine Hospital of Dongli District,Tianjin 300300,China;Department of Traditional Chinese Medicine,Tianjin Binhai New Area Tanggu Street Sanhuai Road Community Health Service Center)
出处
《中国城乡企业卫生》
2021年第10期159-161,共3页
Chinese Journal of Urban and Rural Enterprise Hygiene
关键词
慢性阻塞性肺疾病
急性加重期
肺功能
C反应蛋白
Chronic obstructive pulmonary disease
Acute exacerbation
Pulmonary function
C-reactive protein
