摘要
目的探讨清肝宁肺方在肝火犯肺型慢性咳嗽中的疗效及对患者肺功能和血清免疫球蛋白水平的影响。方法选择2018年11月至2020年5月海南省中医院收治的100例肝火犯肺型慢性咳嗽患者,将其随机分为观察组(n=50)和对照组(n=50),对照组给予布地奈德治疗,观察组给予清肝宁肺方治疗,两组均连续治疗30 d。比较两组的临床疗效;中医证候评分;肺功能[用力肺活量(FVC)、第1秒用力呼气量(FEV1)、最大呼气峰流量(PEF)、用力呼气25%、50%、75%肺活量的瞬间流量(FEF 25%、FEF 50%、FEF 75%)];免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM);不良反应发生率。结果观察组的总有效率显著高于对照组(P<0.05)。与治疗前相比,两组治疗后的中医证候评分均显著下降(P<0.05),且观察组显著低于对照组(P<0.05)。与治疗前相比,治疗后两组的FVC、FEV1、PEF、FEF 25%、FEF 50%、FEF 75%均明显升高(P<0.05),且观察组均较对照组升高更为显著(P<0.05);与治疗前相比,治疗后对照组的血清IgG、IgA、IgM水平略有上升,但差异无统计学意义(P>0.05),治疗后观察组患者的血清IgG、IgA、IgM水平较治疗前明显上升(P<0.05)。观察组不良反应发生率显著低于对照组(P<0.05)。结论清肝宁肺方能有效改善肝火犯肺型慢性咳嗽患者的临床症状、肺功能及免疫功能,且安全性较高。
Objective To explore the curative effect of Qingganningfei Recipe on chronic cough patients with liver fire invading lung and its influence on lung function and serum immunoglobulin level.Methods A total of 100 chronic cough patients with liver fire invading lung admitted to Hainan Provincial Hospital of Traditional Chinese Medicine from November 2018 to May 2020 were enrolled.They were equally divided into the observation group and the control group according to random number table methods.Patients in the control group received budesonide,and observation group were given Qingganningfei Recipe.Both groups were treated continuously for 30 days.The clinical efficacy,Chinese medicine symptom complex score,pulmonary function[forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),maximum peak expiratory flow(PEF),momentary flow of forced expiratory 25%,50%,75%vital capacity(FEF 25%,FEF 50%,FEF 75%)],immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM),and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).Compared with before treatment,Chinese medicine symptom complex score in both groups decreased significantly after treatment(P<0.05),and the scores of the observation group were significantly lower than those in the control group(P<0.05).FVC,FEV1,PEF,FEF 25%,FEF 50%,FEF 75%in the two groups were significantly increased after treatment(P<0.05),and the observation group were significantly higher than those in the control group(P<0.05).Besides,the levels of serum IgG,IgA and IgM in the control group decreased slightly after treatment,but there was no significant difference(P>0.05).The levels of serum IgG,IgA and IgM in the observation group increased significantly after treatment(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Qingganningfei Recipe can effectively improve the clinical symptoms,pulmonary function,immune function,and with high safety in patients of chronic cough with liver fire invading lung.
作者
周明萍
吕佳杰
冯超
王秀兰
陈真娥
ZHOU Mingping;LV Jiajie;FENG Chao;WANG Xiulan;CHEN Zhen'e(Hainan Provincial Hospital of Traditional Chinese Medicine,Haikou,Hainan 570203,China)
出处
《湖南中医药大学学报》
CAS
2021年第11期1802-1806,共5页
Journal of Hunan University of Chinese Medicine
基金
海南省卫生计生行业科研项目(18A200090)。
关键词
慢性咳嗽
清肝宁肺方
肺功能
免疫功能
chronic cough
Qingganningfei Recipe
lung function
immune function
