摘要
目的:了解妇产专科医院门诊绝经综合征患者性激素类药物的使用情况,为绝经妇女健康保健提供相关数据资料。方法:回顾性分析2019年复旦大学附属妇产科医院(以下简称“我院”)门诊临床诊断含“绝经”或“更年期”的处方中性激素类药物的使用情况,对患者年龄、药物品种等进行整理与分析。结果:共收集处方12268张,其中使用性激素类药物的处方为5808张(占47.34%),涉及患者5808例。使用性激素类药物患者的平均年龄为(48.85±5.39)岁,其中40~<50岁患者3299例,50~<60岁患者2216例,≥60岁患者189例,35~<40岁患者104例。5808张处方涉及14种性激素类药物(总用药例次数为6102例次),例次数排序居前3位的药品依次为雌二醇片/雌二醇地屈孕酮片复合包装(2521例次)、替勃龙片(1832例次)和地屈孕酮片(499例次)。不同年龄段患者性激素类药物的使用各有特点,40~<50岁患者中,雌二醇片/雌二醇地屈孕酮片复合包装的使用例次数最多,为1954例次(占该药总使用例次数的77.51%);50~<60岁患者中,替勃龙片的使用例次数最多,为1151例次(占该药总使用例次数的62.83%),此外,该年龄段患者中阴道局部用雌激素制剂使用例次数亦最多;≥60岁患者使用的性激素类药物以替勃龙片、阴道局部用雌激素制剂为主;35~<40岁患者使用的性激素类药物以雌二醇片/雌二醇地屈孕酮片复合包装、替勃龙片为主;不同年龄段患者使用性激素类药物品种的差异具有统计学意义(Fisher确切概率检验,P<0.001)。结论:我院不同年龄段绝经综合征患者使用性激素类药物各有特点,可为绝经激素治疗的个体化方案选择提供参考。
OBJECTIVE:To investigate the application of sex hormone drugs in patients with menopausal syndrome in outpatient department of obstetrics and gynecology hospital,so as to provide relevant data for health care of menopausal women.METHODS:Retrospective analysis was performed on the application of sex hormone drugs drugs in prescriptions clinically diagnosed as“menopause”or“climacterium”in outpatient department of Obstetrics and Gynecology Hospital of Fudan University(hereinafter referred to as“our Hospital”)in 2019,and the age and drug types of patients were sorted out and analyzed.RESULTS:A total of 12268 prescriptions were enrolled,of which 5808 prescriptions(47.34%)were for the application of sex hormone drugs,including 5808 patients.The mean age of patients with sex hormone drugs was(48.85±5.39)years,including 3299 patients aged from 40 to<50 years,2216 patients aged from 50 to<60 years,189 patients aged≥60 years,and 104 patients aged from 35 to<40 years.There were 14 kinds of sex hormone drugs prescribed in 5808 prescriptions(with total number of drug use case-times of 6102),and the top 3 prescriptions were complex packing estradiol tablets/estradiol and dydrogesterone tablets(2521 case-times),tibolon tablets(1832 case-times)and diprogesterone tablets(499 case-times).The application of sex hormone drugs in different age groups had its own characteristics.Among patients aged from 40 to<50 years,the use of complex packing estradiol tablets/estradiol and dydrogesterone tablets was the most(1954 case-times,accounting for 77.51%of the total number of drug use case-times).Among patients aged from 50 to<60 years,the use of tibolon tablets was the most(1151 case-times,accounting for 62.83%of the total number of drug use case-times),in addition,topical vaginal estrogen preparations were used most frequently in this age group.The application of sex hormone drugs in patients aged≥60 years was based on tibolone tablets and topical estrogen preparations for vaginal application.Complex packing estradiol tablets/estradiol and dydrogesterone tablets and tibolon tablets were used as the main drugs in patients aged from 35 to<40 years.There were statistically significant differences in the application of sex hormone drugs in different age groups(Fisher exact probability test,P<0.001).CONCLUSIONS:Different age groups of patients with menopausal syndrome in our hospital have their own characteristics in the application of sex hormone therapy,which can provide reference for the individualized treatment of menopausal hormone.
作者
王先利
金经
汤静
WANG Xianli;JIN Jing;TANG Jing(Dept.of Pharmacy,Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200011,China)
出处
《中国医院用药评价与分析》
2021年第11期1388-1391,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
上海市“医苑新星”青年医学人才培养资助计划项目(沪卫计人事〔2019〕72号)
上海市卫生健康委员会卫生行业临床研究专项面上项目(No.201940153)。
关键词
绝经综合征
性激素
妇女健康保健
绝经激素治疗
Menopausal syndrome
Sex hormone
Women s health care
Menopause hormone therapy
