摘要
钠钾三磷酸腺苷酶(Na^(+)/K^(+)-ATPase,NKA)是一种跨质膜转运钠钾离子的离子泵,对维持细胞内外渗透压平衡至关重要。钠钾三磷酸腺苷酶是由α亚基(亚基α1~α4)和β亚基(亚基β1~β3)及调节亚基组成的多聚体。已发现钠钾三磷酸腺苷酶参与调节与肿瘤细胞存活相关多种信号通路,抑制肿瘤细胞增殖。钠钾三磷酸腺苷酶抑制剂可通过诱导肿瘤细胞自噬凋亡,阻滞细胞周期等发挥抗肿瘤作用。本文旨在综述钠钾三磷酸腺苷酶在肿瘤发展转移中的作用,提高对钠钾三磷酸腺苷酶作为肿瘤治疗的潜在靶标的认识。
Na^(+)/K^(+)-ATPase is an ion pump that transports sodium and potassium ions across the plasma membrane,which is essential for maintaining the balance of osmotic pressure inside and outside the cell.Na^(+)/K^(+)-ATPase is a polymer composed ofαsubunits(subunitsα1~α4),βsubunits(subunitsβ1~β3)and regulatory subunits.It has been found that Na^(+)/K^(+)-ATPase participates in the regulation of multiple sig Nal pathways related to tumor cell survival,thereby inhibiting tumor cell proliferation.Na^(+)/K^(+)-ATPase inhibitors can exert anti-tumor effects by inducing autophagy and apoptosis of tumor cells and blocking cell cycle.This article aimed to review the role of Na^(+)/K^(+)-ATPase in tumor development and metastasis,and to improve the understanding of Na^(+)/K^(+)-ATPase as a potential target for tumor therapy.
作者
张叶
李娴静
杨勇
ZHANG Ye;LI Xianjing;YANG Yong(Center for New Drug Safety Evaluation and Research,China Pharmaceutical University,Nanjing 211198,China;School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 211198,China)
出处
《药学研究》
CAS
2021年第11期760-764,共5页
Journal of Pharmaceutical Research
基金
国家自然科学基金青年基金项目(No.81703562)。
