摘要
【目的】分析2013—2017年山东省耐多药肺结核(multidrug resistant tuberculosis,MDR-TB)患者治疗转归情况,探讨全球基金耐多药防治项目(后称“项目”)结束对MDR-TB患者治疗转归的影响,为MDR-TB防治策略制定提供依据。【方法】从“结核病管理信息系统”收集2013—2017年山东省MDR-TB患者信息,利用Excel软件进行统计分析;描述性分析全省、5个项目市、非项目市MDRTB发现患者数、纳入治疗率、成功治疗率;SPSS 16.0统计软件进行数据分析,率之间的比较采用χ^(2)检验,P<0.05为差异有统计学意义。【结果】全省成功治疗率2014年最高(53.85%),2017年最低(22.93%),差异有统计学意义(χ^(2)=40.96,P<0.001);全省纳入治疗率逐年增加,从66.97%增至85.06%,差异具有统计学意义(χ^(2)=30.53,P<0.001);成功治疗率前4年均在46%以上,2017年下降至22.93%,差异具有统计学意义(χ^(2)=40.96,P<0.001);患者丢失比例2014年后逐年上升,2017年达70.95%,差异具有统计学意义(χ^(2)=2.32,P<0.001);2017年5个项目市发现患者数均为5年最低值。【结论】项目结束对山东省MDR-TB患者发现、治疗、管理均产生了影响,省级层面加大重视、积极探索针对MDR-TB的防治策略迫在眉睫。
[Objectives]To analyze the outcome of treatment of patients with multidrug-resistant tuberculosis(MDR-TB)in Shandong Province from 2013 to 2017,and to discuss the impact of the global fund's multi-drug prevention and control program(hereinafter referred to as“the Program”)on the outcome of treatment of MDR-TB patients,so as to provide a basis for the formulation of MDR-TB prevention and control strategy in Shandong Province.[Methods]Information of MDR-TB patients in Shandong Province from 2013 to 2017 was collected from the TB Management Information System,and Excel was used for statistical analysis.Descriptive analysis was conducted on the number of MDR-TB patients found,treatment rate,and successful treatment rate in the province,5 project cities,and other nonproject cities.SPSS16.0 statistical software was used for data analysis.Chi-square test was performed for comparison between rates(P<0.05).[Result]The successful treatment rate in the province was the highest in 2014(53.85%)and the lowest in 2017(22.93%),with a statistically significant difference(χ^(2)=40.96,P<0.001).The treatment rate in the whole province increased year by year,from 66.97%to 85.06%,and the difference was statistically significant(χ^(2)=30.53,P<0.001).The successful treatment rate was above 46%every year between 2013 and 2016,and decreased to 22.93%in 2017,with a statistically significant difference(χ^(2)=40.96,P<0.001).The proportion of lost patients increased year by year since 2014,reaching 70.95%in 2017,with a statistically significant difference(χ^(2)=2.32,P<0.001).In 2017,the number of patients found in the five project cities was the lowest in five years.[Conclusion]The result of the project has an impact on the discovery,treatment and management of MDR-TB patients in Shandong Province.There is an urgent need to pay more attention to and actively explore prevention and treatment strategies for MDR-TB at the provincial level.
作者
王倩
张修磊
郭肖岩
WANG Qian;ZHANG Xiu-lei;GUO Xiao-yan(Department of Tuberculosis Control and Prevention,Shandong Chest Hospital,Jinan,Shandong 250101,China)
出处
《上海预防医学》
CAS
2021年第11期1031-1034,共4页
Shanghai Journal of Preventive Medicine
关键词
耐多药肺结核
治疗转归
项目
multidrug resistant tuberculosis
treatment outcome
project
