摘要
阿尔茨海默病(Alzheimer’s disease, AD)是最常见的神经退行性疾病之一,它主要的病理学标志包括神经纤维缠结(neurofibrillary tangles)和老年斑(senile plaque)形成,其发病机制极为复杂。Akt作为胰岛素信号通路的主要因子在调节细胞生长、能量利用、线粒体功能、自噬、氧化应激、突触可塑性及认知功能等方面发挥重要作用。研究显示AD患者脑中Akt存在不同的翻译后修饰的变化,提示Akt的不同翻译后修饰可能与AD的发病过程密切相关。本文从Akt切入,阐述其在AD发病机制中的可能作用,以期为AD的预防与治疗提供新线索。
Alzheimer’s disease(AD) is one of the most common neurodegenerative diseases. Its main pathological markers include neurofibrillary tangle and senile plaque formation, and its pathogenesis is extremely complex. As the main factor of the insulin signaling pathway, Akt plays an important role in regulating cell growth, energy utilization, mitochondrial functions, autophagy, oxidative stress, synaptic plasticity and cognitive functions. Studies have shown different post-translational modifications of Akt in the brains of AD patients, which suggests that different post-translational modifications of Akt may be closely related to the pathogenesis of AD. In this review, the possible role of Akt in the pathogenesis of AD was discussed, in order to provide new clues for the prevention and treatment of AD.
作者
王卯
宋军营
张振强
WANG Mao;SONG Junying;ZHANG Zhenqiang(the First Clinical Medical College of Henan University of Traditional Chinese Medicine Academy,Zhengzhou 450000,China;College of traditional Chinese Medicine,Henan University of Traditional Chinese Medicine Academy,Zhengzhou 450046)
出处
《中国比较医学杂志》
CAS
北大核心
2021年第11期114-118,126,共6页
Chinese Journal of Comparative Medicine
基金
国家自然基金联合基金项目(U1504829)
中原科技领军人才项目(204200510022)
河南省重点研发与推广专项项目(192102310214)
河南省中医药科学研究专项重点课题(2018ZY1009)
河南省高等学校重点科研项目计划(19A360021)。
