摘要
目的分析妊娠糖尿病患者用盐酸二甲双胍联合门冬胰岛素治疗的效果。方法选取2019年12月—2021年6月该院收治的74例妊娠糖尿病患者为研究对象,将患者随机单盲法分组,各37例。对照组为门冬胰岛素治疗,观察组联合盐酸二甲双胍药物,分析疗效。结果治疗前,两组患者的指标数据比较,差异无统计学意义(P>0.05)。治疗后,观察组患者的空腹血糖、餐后2 h血糖、糖化血红蛋白数据较对照组更低;观察组出现不良事件的发生率较对照组低,差异有统计学意义(P<0.05);观察组同型半胱氨酸、胱抑素C指标数据和对照组相比更低,血糖达标时间更短,出现低血糖事件更少,差异有统计学意义(P<0.05)。结论盐酸二甲双胍联合门冬胰岛素治疗妊娠糖尿病效果显著,有效改善血糖状况,提升分娩的安全度,减少不良事件的出现,有效改善妊娠结局,对产妇和胎儿都有利,具备治疗优势,值得推广。
Objective To analyze the effect of the combination of metformin for winter insulin therapy in gestational diabetic patients.Methods 74 patients with gestational diabetes mellitus treated in the hospital from December 2019 to June 2021 were selected as the research objects.The patients were randomly divided into 37 cases by single blind method.The patients were randomly divided into groups,37 cases in each group.The control group was treated with insulin aspart,and the observation group was combined with metformin hydrochloride to analyze the curative effect.Results Before treatment,the comparison of the index data of the two groups of patients showed no statistically significant difference(P>0.05).After treatment,the data of fasting blood glucose,2 h postprandial blood glucose,and glycosylated hemoglobin of the observation group were lower than those of the control group,and the incidence of adverse events in the observation group was lower than that of the control group,the difference was statistically significant(P<0.05),after treatment,the observation group’s homocysteine and cystatin C index data were lower than those of the control group,the blood glucose reaching the target time was shorter,and there were fewer hypoglycemia events,and the difference was statistically significant(P<0.05).Conclusion The treatment of gestational diabetes with metformin-combined meningococcal insulin has remarkable effect,effectively improving blood sugar condition,improving the safety of childbirth,reducing the appearance of adverse events,effectively improving pregnancy outcomes,benefiting both mother and fetus,and having the advantages of treatment,and is worth popularizing.
作者
康高杨
刘俐彤
KANG Gaoyang;LIU Litong(Department of Obstetrics and Gynecology,Qiqihar First Hospital,Qiqihar,Heilongjiang Province,161000 China)
出处
《糖尿病新世界》
2021年第19期74-77,共4页
Diabetes New World Magazine
关键词
妊娠糖尿病
盐酸二甲双胍
门冬胰岛素
低血糖
妊娠结局
Gestational diabetes
Metformin hydrochloric acid
Mendon insulin
Low blood sugar
Pregnancy outcome
