摘要
目的探究痹祺胶囊联合刃针治疗早期膝骨性关节炎(knee osteoarthritis,KOA)的疗效。方法采用随机数字表法将70例KOA患者随机分成2组,各35例。2组患者均用刃针治疗,1次/周,共2次;对照组患者联合口服塞来昔布胶囊200 mg/次,1次/d;试验组患者联合口服痹祺胶囊1.2 g/次,3次/d;治疗14 d。比较治疗前后及3个月随访的视觉模拟评分(visual analogue scale,VAS)及西安大略和麦克马斯特大学(Western Ontario and McMaster University,WOMAC)骨关节炎指数量表评分来判定疗效。结果纳入研究的70例KOA患者中有8例脱落,共有62例纳入分析。2组治疗后VAS及WOMAC评分较治疗前均显著降低(P<0.01),但对照组比试验组的VAS分值降低更明显(P<0.05),WOMAC评分在治疗2周后和3个月随访均为试验组降低更明显(P<0.05)。治疗2周后,2组有效率较接近(试验组96.9%,对照组90%),3个月随访试验组有效率(93.8%)优于对照组(63.3%)(P<0.01)。结论采用痹祺胶囊联合刃针与塞来昔布联合刃针治疗KOA均疗效显著,但痹祺胶囊联合刃针改善关节功能更明显,且疗效更稳定持久。
Objective To explore the clinical efficacy of Biqi Capsules(痹祺胶囊)combined with blade acupuncture in the treatment of knee osteoarthritis(KOA)in the early stage.Methods A total of 70 patients with KOA were randomly divided into two groups according to the random number table method,35 cases in each group.The two groups were treated with blade acupuncture,once a week,twice in total.The patients in the control group were treated Celecoxib Capsules 200 mg/time,once a day;patients in the experimental group were treated Biqi Capsules 1.2 g/time,3 time/d at the same time,two weeks a course of treatment.The clinical efficacy was assessed by comparing the scores of visual analogue scale(VAS)and Western Ontario and McMaster University(WOMAC)osteoarthritis index scale score before and after the treatment.Results Eight patients among the 70 participants dropped out,while other 62 patients were enrolled in this research.The two groups both had distinct reduction in the VAS scores and WOMAC scores after the treatment(P<0.01).However the control group had a more significant reduction in VAS scores(P<0.05),the experimental group had a more significant reduction in WOMAC scores after the treatment and the follow-up survey in three months later(P<0.05).The effective rates of the two groups were similar(experimental group 96.9%,control group 90%)after the treatment,but the effective rate of the experimental group(93.8%)was better than that of the control group(63.3%)at three month follow-up(P<0.01).Conclusion Biqi Capsules combined with blade acupuncture and Celeoxib combined with blade acupuncture had significant efficacy can effectively improve clinical symptoms of patients with KOA in the early stage,but the experimental group has a more lasting and stable curative effect.
作者
宋阳春
吴三兵
胡谷丰
张芬
SONG Yang-chun;WU San-bing;HU Gu-feng;ZHANG Fen(The Second Department of Orthopaedics and Traumatology,the Second Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230061,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第22期6923-6927,共5页
Chinese Traditional and Herbal Drugs
基金
安徽省教育厅自然科学研究项目(KJ2013Z165)
安徽省科技攻关项目(1704a0802168)。
