摘要
目的:观察茯苓解毒方加减联合盐酸坦索罗辛缓释胶囊治疗男性非淋菌性尿道炎对患者炎症因子的影响。方法:选取我院门诊于2018年5月~2020年5月收治的男性非淋菌性尿道炎患者100例,根据治疗方法分为两组,每组50例。对照组给予盐酸坦索罗辛缓释胶囊联合吲哚美辛肠溶片治疗,观察组在对照组基础上给予茯苓解毒方加减治疗。记录两组症状评分、炎症因子的变化,并统计两组总有效率、不良反应率及复发率。结果:治疗前,两组症状评分组间比较,无统计学意义(P>0.05)。治疗后,两组尿道灼痒、尿急、尿频及尿痛评分较治疗前下降(P<0.05),观察组上述症状评分均低于对照组(P<0.05)。治疗前,两组炎症因子水平组间比较,无统计学意义(P>0.05)。治疗后,两组高敏-C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平较治疗前下降(P<0.05),观察组上述因子均低于对照组(P<0.05)。观察组的总有效率为96.00%(48/50),高于对照组的82.00%(41/50),组间比较发现,有统计学意义(P<0.05)。观察组的不良反应率为10.00%(5/50),与对照组的8.00%(4/50)进行组间比较发现,无统计学意义(P>0.05)。随访6个月,发现观察组的复发率为10.00%(5/50),低于对照组的26.00%(13/50),组间比较发现,有统计学意义(P<0.05)。结论:茯苓解毒方加减联合盐酸坦索罗辛缓释胶囊治疗男性非淋菌性尿道炎可减轻炎症反应,改善症状,提高疗效,减少复发。
Objective: To observe the effect of Modified Fuling Jiedu Recipe combined with Tansorosin Hydrochloride Sustained-release Capsule on inflammatory factors for male non-gonococcal urethritis. Methods: 100 cases of male non-gonococcal urethritis treated in outpatient of our hospital from May 2018 to May 2020 were divided into two groups according to the treatment method, 50 cases in each group. The controlled group was treated with Tansorosin Hydrochloride Sustained-release Capsule combined with Indomethacin Enteric-coated Tablets, and the observation group was treated with Modified Fuling Jiedu Recipe on the basis of the controlled group. The changes of symptom score and inflammatory factors were recorded, and the total effective rate, adverse reaction rate and recurrence rate were counted. Results: Before treatment, there was no significant difference between the two groups(P > 0.05). The scores of urinary itching, urgency, frequency and pain in the two groups were lower than those in the controlled group(P < 0.05) after treatment. Before treatment, there was no significant difference between the two groups(P > 0.05). The levels of high sensitivity-C reactive protein(hs-CRP),interleukin-6(IL-6) and interleukin-8(IL-8) in the two groups decreased(P < 0.05) compared with those in the controlled group(P < 0.05). The total effective rate in the observation group was 96.00%(48/50),higher than that in the controlled group(82.00%,41/50)(P < 0.05). Adverse reaction rate in the observation group was 10.00%(5/50),compared with 8.00%(4/50) in the controlled group, there was no significant difference(P > 0.05). After 6 months of follow-up, the recurrence rate in the observation group was 10.00%(5/50),which was lower than that in the controlled group(26.00%,13/50). The comparison between the two groups was statistically significant(P < 0.05). Conclusion: Treatment of male non-gonococcal urethritis with Modified Fuling Jiedu Recipe combined with Tansorosin Hydrochloride Sustained-release Capsule can alleviate inflammatory reaction, improve symptoms, improve curative effect and reduce recurrence.
作者
王麦绒
贺利明
WANG Mairong;HE Liming(Department of Traditiomal Chinese Medicine and Acupuncture,School Hospital of Xianyang Normal University,Xianyang Shaanxi 712000,China;Department of Urology,Yulin Hospital of Traditional Chinese Medicine,Yulin Shaanxi 719000,China)
出处
《四川中医》
2021年第11期149-152,共4页
Journal of Sichuan of Traditional Chinese Medicine
关键词
茯苓解毒方
盐酸坦索罗辛缓释胶囊
非淋菌性尿道炎
炎症因子
Fuling Jiedu Recipe
Tansorosin Hydrochloride Sustained Release Capsule
Male
Non-gonococcal urethritis
Inflammatory factors
