摘要
目的:探讨T_(1)-mapping技术在甲状腺相关眼病(TAO)临床分期中的应用价值。方法:回顾性分析50例TAO患者的临床和影像资料,测量每例患者4条眼外肌中信号强度最高(“热点”)和最低区域(“冷点”)的T_(1)弛豫时间(T_(1)RT),比较活动期组和非活动期组之间热点和冷点T_(1)RT值的差异,并采用受试者工作特征曲线评估T_(1)RT在TAO分期中的诊断效能。结果:活动期组眼外肌T_(1)RT的冷点值显著高于非活动期组(P<0.001),而两组间眼外肌的T_(1)RT热点值的差异无统计学意义(P=0.122)。T_(1)RT冷点值与临床活动性评分呈正相关(r=0.501,P<0.001)。以T_(1)RT冷点值≥1000 ms判断TAO处于活动期的效能最优(曲线下面积为0.815,敏感度为80.6%,特异度为71.1%)。结论:T_(1)-mapping技术在甲状腺相关眼病分期中具有临床应用价值,眼外肌T_(1)RT冷点值可作为预测甲状腺相关眼病分期的指标。
Objective:To assess the staging value of MR T_(1)-mapping technique in patients with thyroid-associated ophthalmopathy(TAO).Methods:Fifty TAO patients were retrospectively enrolled.T_(1)-relaxation time of hot spot and cold spot(T_(1)RT-HS and T_(1)RT-CS)in four extraocular muscles(EOMs)were measured and compared between patients with active and inactive TAO.Receiver operating characteristic curve(ROC)was used to evaluate the staging value of significant variables.Results:T_(1)RT-CS was significantly higher in active group than that in inactive group(P<0.001),while T_(1)RT-HS was not(P=0.122).Correlation analysis showed that T_(1)RT-CS positively correlated with clinical activity score(r=0.501,P<0.001).Taking T_(1)RT-CS≥1000ms as the standard for diagnosing active stage of TAO had the optimal staging efficacy,the area under ROC was 0.815,with sensitivity of 80.6%,and specificity of 71.1%.Conclusion:T_(1)-mapping technique could be used to evaluate the stage of TAOs in clinical practice,and the derived T_(1)RT-CS of extraocular muscles could be a useful imaging biomarker for predicting the stage of the disease.
作者
滕剑
胡昊
许晓泉
吴飞云
张宗军
TENG Jian;HU Hao;XU Xiao-quan(Department of Radiology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)
出处
《放射学实践》
CSCD
北大核心
2021年第12期1499-1502,共4页
Radiologic Practice
基金
江苏省妇幼保健协会科研项目(TS201906)。
