摘要
笑气(一氧化二氮)因价格低廉、容易获得,目前存在滥用情况。本文探讨1例吸食笑气致脊髓亚急性联合变性患者的临床表现,患者出现四肢麻木、步态不稳,血清维生素B_(12)水平降低,颈椎MRI提示颈髓(C2-6)侧索及后索内节段性异常信号;神经电生理检查示四肢周围神经损害。经补充维生素B_(12)治疗,患者病情逐渐好转。临床医生诊断脊髓亚急性联合变性,尤其患者无消化道疾病、节食、营养不良等情况时,需仔细询问有无吸食笑气史,避免漏诊。
Laughing gas(Nitrogen monoxide)is currently abused due to its low price and easy availability.This article discussed the clinical manifestations of a patient with subacute combined degeneration of the spinal cord caused by inhalation of laughing gas.The patient developed numbness of extremities,unstable walking,and decreased serum vitamin B_(12) level.MRI of the cervical spine showed abnormal signals in the lateral and posterior cords of the cervical spinal cord(C2-6),neuroelectrophysiological examination showed peripheral nerve damage in the extremities.After treatment with vitamin B_(12) supplementation,the patient's condition gradually improved.Clinicians diagnose subacute combined degeneration of the spinal cord,especially when the patient has no gastrointestinal disease,diet,malnutrition,etc.,they need to carefully inquire about the history of nitrous oxide inhalation to avoid missed diagnosis.
作者
刘杨
王志晔
张作念
倪梦园
陆兆敏
潘锡近
Liu Yang;Wang Zhiye;Zhang Zuonlan;Ni Mengyuan;Lu Zhaomin;Pan Xijin(Department of Neurology,Nanjing Meishan Hospital,Nanjing 210039,China;Department of Neurology,Drum Tower Hospital,Nanjing University,Nanjing 210000,China)
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2021年第11期868-870,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词
吸入剂滥用
中毒
笑气
一氧化二氮
脊髓亚急性联合变性
Inhalant abuse
Poisoning
Laughing gas
Nitrous oxide
Subacute combined degeneration of spinal cord
