摘要
目的探讨雷氏隔姜脐灸疗法治疗溃疡性结肠炎(UC)脾虚湿蕴证的效果及其作用机制。方法70例UC患者随机分为对照组和观察组,每组各35例。对照组给予美沙拉嗪肠溶片口服,观察组在对照组基础上予以雷氏隔姜脐灸治疗,疗程为4周。比较两组的中医症状积分、血清炎症因子水平、外周血T淋巴细胞亚群计数,并进行临床疗效评价。结果治疗后,两组的中医症状积分均较治疗前减低(P<0.05),观察组的中医症状积分低于对照组(P<0.05);两组的血清hs-CRP、TNF-α、IL-6水平较治疗前明显降低(P<0.05),观察组的血清炎症因子水平低于对照组(i><0.05);两组的外周血T淋巴细胞亚群计数均较治疗前明显好转(P<0.05),观察组的CD3^(+)、CD4^(+)与CD4^(+)/CD8^(+)水平均高于对照组(P<0.05),CD8+水平低于对照组(P<0.05)。观察组的总有效率为93.75%,对照组的总有效率为72.73%,差异有统计学意义(P<0.05)。在治疗期间,两组均未见明显不良反应。结论雷氏隔姜脐灸疗法治疗UC疗效满意,且副作用少。
Objective To investigate the effect and mechanism of LEI's ginger-umbilical moxibustion therapy on ulcerative colitis(UC)of spleen deficiency and dampness accumulation syndrome.Methods Seventy UC patients were randomly divided into control group and observation group,with 35 cases in each group.The control group was given mesalazine enteric-coated tablets oraUy,and the observation group was treated with LEI's ginger-umbilical moxibustion therapy on the basis of the control group.The course of treatment was 4 weeks.The scores of TCM symptoms,serum inflammatory factors and peripheral blood T lymphocyte subsets were compared between the two groups,and the clinical efficacy was evaluated.Results After treatment,the TCM symptom score of both groups was lower than that before treatment(P<0.05),and the TCM symptom score of observation group was lower than that of control group(P<0.05).The levek of serum hs-CRP,TNF-α and IL-6 in 2 groups were significantly lower than those before treatment(P<0.05),and the level of serum inflammatory factors in observation group was lower than that in control group(P<0.05).The T lymphocyte subsets of peripheral blood in both groups were significantly improved compared with those before treatment(P<0.05),the levels of CD3^(+),CD4^(+) and CD4^(+)/CD8^(+) in observation group were higher than those in control group(P<0.05),and the CD8^(+) level was lower than that in control group(P<0.05).The total effective rate of the observation group was 93.75%,and that of the control group was 72.73%,with statistical significance(P<0.05).During the treatment period,no obvious adverse reactions were observed in both groups.Conclusion LEI's ginger-umbilical moxibustion therapy is reliable in treating UC with few side effects.
出处
《浙江临床医学》
2021年第12期1749-1752,共4页
Zhejiang Clinical Medical Journal
基金
全国中医临床特色技术传承骨干人才培训项目(国中医药人教函[2019]36号)
浙江省中医药科技计划项目(2021ZB324、2020ZB289、2016ZB137)
浙江省科技计划项目(2015C33274)。
关键词
雷氏膈姜脐灸疗法
溃疡性结肠炎
脾虚湿蕴型
疗效评价
作用机制
LEI's ginger-umbilical moxibustion therapy
Ulcerative colitis
Spleen deficiency with dampness accumulation syndrome
Therapeutic evaluation Mechanism
