摘要
目的探讨康柏西普注射液联合532 nm激光全视网膜光凝术治疗糖尿病视网膜病变(DR)的效果及对眼底微循环的影响。方法选取2017年3月至2020年3月江苏省苏州市第九人民医院收治的82例(96眼)DR患者,依照随机数字表法将其分为观察组(41例,50眼)和对照组(41例,46眼)。对照组采用532 nm激光全视网膜光凝术治疗,观察组在对照组的基础上另给予康柏西普注射液治疗。比较两组斑中心凹视网膜厚度(CMT)、最佳矫正视力(BCVA)、眼压、临床疗效及眼底微循环情况。结果治疗前两组CMT、BCVA和眼压比较,差异均无统计学意义(P>0.05);治疗后6个月,两组CMT均降低,且观察组低于对照组(P<0.05),BCVA均升高,且观察组高于对照组(P<0.05);两组眼压比较,差异无统计学意义(P>0.05)。治疗后6个月,两组临床疗效比较,差异有统计学意义(P<0.05)。治疗前两组血浆黏度(PV)、红细胞聚集指数(EAI)、红细胞变形指数(EDI)、红细胞沉降率(ESR)、红细胞压积(Hct)比较,差异均无统计学意义(P>0.05);治疗后6个月,两组PV、EAI、EDI、ESR和Hct均降低(P<0.05),且观察组低于对照组(P<0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。结论DR患者采用康柏西普注射液联合532 nm激光全视网膜光凝术治疗能够降低CMT,提高视力,疗效确切,同时能够改善眼底微循环。
Objective To explore the effect of Conbercept Injection combined with 532 nm laser panretinal photocoagulation in the treatment of diabetic retinopathy(DR)and its influence on fundus microcirculation.Methods Eighty-two patients(96 eyes)with DR admitted to the Ninth People’s Hospital of Suzhou City from March 2017 to March 2020 were selected and they were divided into observation group(41 cases,50 eyes)and control group(41 cases,46 eyes)according to the random number table method.The control group was treated with 532 nm laser panretinal photocoagulation,and the observation group was treated with Conbercept Injection on the basis of the control group.Retinal fovea thickness(CMT),best corrected visual acuity(BCVA),intraocular pressure,clinical efficacy,and fundus microcirculation were compared between the two groups.Results There were no significant differences in CMT,BCVA,and intraocular pressure between the two groups before treatment(P>0.05);six months after treatment,CMT in both groups was decreased,and the observation group was lower than that of the control group(P<0.05),BCVA was increased,and the observation group was higher than that of the control group(P<0.05).There was no statistical significance in intraocular pressure between the two groups(P>0.05).Six months after treatment,there was a significant difference in clinical effects between the two groups(P<0.05).There were no statistically significant differences in plasma viscosity(PV),erythrocyte aggregation index(EAI),erythrocyte deformation index(EDI),erythrocyte sedimentation rate(ESR),and hematocrit(Hct)between the two groups before treatment(P>0.05);six months after treatment,PV,EAI,EDI,ESR,and Hct in both groups were decreased(P<0.05),and which in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion The treatment of DR patients with conbercept injection combined with 532 nm laser panretinal photocoagulation can reduce CMT,improve vision,and has a definite effect,and it can improve the fundus microcirculation.
作者
徐静
沈毅飞
XU Jing;SHEN Yifei(Department of Ophthalmology,Ninth People’s Hospital of Suzhou City,Jiangsu Province,Suzhou215200,China)
出处
《中国医药导报》
CAS
2021年第36期73-76,共4页
China Medical Herald
基金
江苏省自然科学基金项目(BK20191077)。
