摘要
目的探讨多学科症状管理对肺癌患者免疫治疗所致皮肤毒性反应症状的效果。方法选取上海市胸科医院肿瘤内科病房收治的115例肺癌免疫治疗患者,实施药物及非药物治疗相结合的症状管理措施。药物干预包括抗过敏及类固醇激素类用药;非药物干预包括放松疗法及润肤剂应用等。结果实施症状管理后,免疫治疗所致的皮疹及瘙痒症状较干预前降低,且多数患者皮疹及瘙痒程度为1~2级;除社会与家庭状况外,患者的生理状况、情感状况、功能状况及附加关注度优于症状管理前,差异具有统计学意义(P<0.05)。结论规范化皮肤毒性管理能改善肺癌患者的症状体验,提高患者的生活质量。
Objective To explore the effect of multidisciplinary symptom management on symptoms of skin toxicity caused by immunotherapy in patients with lung cancer. Methods A total of 115 lung cancer patients with immunotherapy in Department of Oncology in Shanghai Chest Hospital were selected and treated with symptom management measures of drug and non-drug treatments in combination. Drug interventions included anti-allergy and steroid drugs, while non-drug interventions included relaxation therapy and application of emollients. Results After the implementation of symptom management, the rash and pruritus symptoms caused by immunotherapy alleviated compared with before intervention(P<0.05), and the rash and pruritus degree in most patients was grade 1 to 2. Except for social and family status, the physiological status, emotional status, functional status and additional attention of patients were significantly better than those before symptom management(P<0.05). Conclusion Standardized skin toxicity management can improve the symptom experience of lung cancer patients and improve the qualities of life of patients.
作者
甘婉玲
韩辰燕
刘晓芯
张铭
GAN Wanling;HAN Chenyan;LIU Xiaoxin;ZHANG Ming(Department of Integrated Traditional Chinese and Western Medicine,the Second Ward of Oncological Department,Shanghai Chest Hospital,Chest Hospital Affiliated to Shanghai Jiaotong University,Shanghai,200030;Department of Nursing,Shanghai Chest Hospital,Chest Hospital Affiliated to Shanghai Jiaotong University,Shanghai,200030)
出处
《实用临床医药杂志》
CAS
2021年第22期21-25,共5页
Journal of Clinical Medicine in Practice
基金
国家自然科学基金委员会面上项目(81873275)
上海市中医专科(专病)联盟建设项目[ZY(2018-2020)-FWTX-4028]
上海交通大学医学院护理科研项目(Jyhz2037)
上海交通大学医学院护理国际交流基金项目(Hlgy1859qnhb)。
关键词
肺肿瘤
免疫治疗
不良反应
皮肤毒性
症状管理
lung cancer
immunotherapy
adverse reactions
skin toxicity
symptom management
