摘要
目的探讨帕金森病(PD)认知障碍患者MRI灌注成像脑血流变化特点及与血清表皮生长因子(EGF)水平的相关性。方法选择杭州市第三人民医院2017年9月至2020年9月诊治的PD患者120例,根据是否出现轻度认知功能损害(MCI)分为PD-MCI组(60例)和PD无认知障碍(PD-NCI)组(60例),另选择同期健康体检者60例作为正常对照组。采用MRI灌注成像评估各组脑血管灌注情况,应用酶联免疫吸附试验法测定各组EGF水平,并进行比较。结果PD-MCI组、PD-NCI组CBF和CBV低于正常对照组,而MTT长于正常对照组[(14.78±2.49)和(18.21±2.84)ml/(100 g·min)比(18.21±2.84)ml/(100 g·min)、(1.42±0.29)和(1.83±0.31)ml/100 g比(2.87±0.54)ml/100 g、(10.53±2.18)和(7.85±1.39)s比(4.29±1.05)s],差异有统计学意义(P<0.05);PD-MCI组CBF和CBV低于PD-NCI组,而MTT长于PD-NCI组,差异有统计学意义(P<0.05)。PD-MCI组和PD-NCI组血清EGF水平低于正常对照组[(146.25±30.12)、(208.17±21.25)ng/L比(242.38±25.46)ng/L],PD-MCI组血清EGF水平低于PD-NCI组,差异有统计学意义(P<0.05)。CBF、CBV和EGF与蒙特利尔认知评估量表(MoCA)评分呈线性正相关(r1=0.810、r2=0.732、r3=0.825,P<0.05),而MTT与MoCA评分呈线性负相关(r4=-0.756,P<0.05)。结论PD-MCI患者存在脑血流异常,且血清EGF水平下降,并且PD-MCI患者CBF、CBV和EGF与MoCA评分呈线性正相关,而MTT与MoCA评分呈线性负相关。
Objective To explore the characteristics of cerebral blood flow changes in MRI perfusion imaging in patients with Parkinson disease(PD)cognition disorders and its correlation with serum epidermal growth factor(EGF)level.Methods One hundred and twenty PD patients diagnosed and treated from September 2017 to September 2020 in Hangzhou Third People′s Hospital were selected.According to the presence of mild cognitive impairment(MCI),they were divided into PD-MCI group(60 cases)and PD without cognition impairment(PD-NCI)group(60 cases).Another 60 cases of healthy physical examination during the same period were selected as the normal control group.MRI perfusion imaging was used to evaluate the cerebral vascular perfusion in each group,and the EGF level of each group was determined by enzyme-linked immunosorbent assay and compared.Results The CBF and CBV in the PD-MCI group and PD-NCI group were lower than those in the normal control group,while the MTT was longer than that in the normal control group:(14.78±2.49),(18.21±2.84)ml/(100 g·min)vs.(18.21±2.84)ml/(100g·min);(1.42±0.29),(1.83±0.31)ml/100 g vs.(2.87±0.54)ml/100 g;(10.53±2.18),(7.85±1.39)s vs.(4.29±1.05)s,and the differences were statistically significant(P<0.05).The CBF and CBV in the PD-MCI group were lower than those in the PD-NCI group,while MTT was longer than that in the PD-NCI group,and the differences were statistically significant(P<0.05).The level of serum EGF in the PD-MCI group and PD-NCI group were lower than those in the normal control group:(146.25±30.12),(208.17±21.25)ng/L vs.(242.38±25.46)ng/L;the level of serum EGF in the PD-MCI group was lower than that in the PD-NCI group,and the differences were statistically significant(P<0.05).CBF,CBV and EGF were linearly positively correlated with Montreal Cognitive Assessment Scale(MoCA)scores(r1=0.810,r2=0.732,r3=0.825,P<0.05),while MTT was linearly negatively correlated with MoCA scores(r4=-0.756,P<0.05).Conclusions PD-MCI patients have abnormal cerebral blood flow,and serum EGF level decrease.In PD-MCI patients,CBF,CBV and EGF are linearly positively correlated with MoCA scores,while MTT is linearly negatively correlated with MoCA scores.
作者
刘慧丽
顾婧
吴春丽
Liu Huili;Gu Jing;Wu Chunli(Department of Neurology,Hangzhou Third People's Hospital,Hangzhou 310009,China)
出处
《中国医师进修杂志》
2021年第12期1137-1140,共4页
Chinese Journal of Postgraduates of Medicine
基金
2017年杭州市卫生计生科技计划一般(A类)项目(2017A20)。
关键词
帕金森病
认知障碍
灌注成像
表皮生长因子
相关性研究
Parkinsondisease
Cognition disorders
Perfusion imaging
Epidermal growth factor
Association studies
