摘要
目的针对序贯放化疗治疗和放化疗治疗在老年局部晚期非小细胞肺癌患者中的应用效果进行观察。方法选取2020年7月至2021年3月江南大学附属医院收治的80例老年局部晚期非小细胞肺癌患者作为研究对象,采用计算机随机数字法分为观察组和对照组,每组各40例。观察组采用同步放化疗治疗,对照组采用序贯放化疗治疗。比较两组的临床治疗效果、生理功能卡氏(KPS)评分、生存质量(SF-36)评分变化情况、治疗不良反应总发生率。结果观察组的临床治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组治疗前的KPS评分、SF-36评分比较,差异无统计学意义(P>0.05);两组治疗后的KPS评分、SF-36评分均高于治疗前,且观察组治疗后的KPS评分、SF-36评分高于对照组,差异有统计学意义(P<0.05);两组的治疗不良反应总发生率比较,差异无统计学意义(P>0.05)。结论针对老年局部晚期非小细胞肺癌患者,同步放化疗治疗在提升疗效、改善患者生存质量方面效果更加显著,方案值得推荐。
Objective To observe the effect of sequential radiochemotherapy and radiochemotherapy in elderly patients with locally advanced non-small cell lung cancer.Methods From July 2020 to March 2021,80 elderly patients with locally advanced non-small cell lung cancer in the Affiliated Hospital of Jiangnan University were used as the research objects.They were divided into observation group and control group by computer random number method,with 40 cases in each group.patient.The observation group were treated with concurrent chemotherapy and radiotherapy,and the control group were treated with sequential chemotherapy and radiotherapy.The clinical treatment effect,physiological function Karnofsky(KPS)score,the Mos item short form health survey(SF-36)score,and the total incidence of adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There were no significant differences in the KPS score and SF-36 score of the two groups before treatment(P>0.05);the KPS score and SF-36 score of the two groups after treatment were higher than those before treatment,and the KPS score and SF-36 score of the observation group after treatment were higher than those of the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion For elderly patients with locally advanced non-small cell lung cancer,concurrent radiotherapy and chemotherapy are more effective in enhancing the efficacy and improving the quality of life of patients,and the program is worth recommending.
作者
陈欢
沈培佩
CHEN Huan;SHEN Peipei(Department of Radiotherapy,Taikang Xianlin Drum Tower Hospital,School of Medicine,Nanjing University,Jiangsu Province,Nanjing210046,China;Department of Abdominal Radiotherapy,Affiliated Hospital of Jiangnan University,Jiangsu Province,Wuxi214000,China)
出处
《中国当代医药》
CAS
2021年第36期77-79,82,共4页
China Modern Medicine
关键词
老年
局部晚期
非小细胞肺癌
序贯放化疗
同步放化疗
临床疗效
Elderly
Locally advanced
Non-Small cell lung cancer
Sequential radiotherapy and chemotherapy
Concurrent Radiotherapy and chemotherapy
Clinical efficacy
