摘要
目的探讨成人不同血尿酸(SUA)水平与空腹血糖受损(IFG)的相关性。方法选择2019年3月至2020年2月江苏省太湖疗养院健康体检的无锡地区成年人群5 006例为研究对象。以SUA水平作为观察指标并按照Q1:SUA<270 μmol/L;Q2:270 μmol/L≤SUA≤318 μmol/L;Q3:319 μmol/L≤SUA≤360 μmol/L;Q4:361 μmol/L≤SUA≤410 μmol/L;Q5:SUA>410 μmol/L五分位法分为五组。相关性采用Logistic分析, 以是否发生IFG作为结局指标, SUA五组为观察指标, 性别、年龄、体质指数(BMI)、血脂、血压作为混杂因素, 构建3个Logistic回归分析模型, 探索不同SUA水平分组与IFG风险之间的关系, 以及BMI对SUA与IFG发生风险相关性的影响。结果 BMI、DBP、FPG、TC、TG、LDL-c随着SUA水平增高而增高, 而HDL-c随之逐渐下降(均P<0.01);五组SUA与IFG组中FPG水平呈正相关(r=0.589, P<0.001)。校正年龄, 性别和BMI后, SUA与IFG组中FPG存在较强相关性(r=0.534, P<0.001)。进一步校正血脂、血压后, 这种相关性依然存在(r=0.523, P<0.001);以Q1为对照组各组计算出的IFG风险的OR值分别为1.199、2.660、2.784、3.629;进一步校正多种混杂因素后各组计算出的OR值分别为1.130、2.389、2.350、2.895。SUA 水平处于相应Q2组和Q5组的人群发生IFG的风险是正常人的1.130倍和2.895倍, 说明随着SUA水平升高, 人群中患IFG风险增加;BMI分层后, 随着BMI及SUA水平的升高, FPG均值呈上升趋势(P<0.001)。结论 SUA水平与IFG风险密切相关。SUA水平升高, IFG风险增加, 且SUA、IFG与体重增加相关联。
Objective To investigate the correlation between different serum uric acid(SUA)levels and impaired fasting glucose(IFG)in adults.Methods From March 2019 to February 2020,5006 adults in Wuxi area of Taihu Sanatorium in Jiangsu Province were selected as subjects.Quintile method was divided into the following five groups:Q1:SUA<270μmol/L,Q2:270μmol/L SUA 318μmol/L or less,Q3:319μmol/L≤SUA≤360μmol/L,Q4:361μmol/L SUA 410μmol/L or less,and Q5:SUA>410μmol/L.Correlation was analyzed by logistic analysis,with IFG as the outcome index,five SUA groups as the observation index,and gender,age,body mass index(BMI),blood lipid,and blood pressure as confounding factors.Three logistic regression analysis models were constructed to explore the relationship between different SUA level groups and IFG risk,as well as the influence of BMI on the risk correlation between SUA and IFG.Results The BMI,DBP,FPG,TC,TG,and LDL-C all increased with the increase in SUA level;however,HDL-C gradually decreased with the increase in SUA level(P<0.01).The SUA levels among the five groups were positively correlated with fasting blood glucose level in the IFG group(r=0.589,P<0.001).After adjusting for age,sex,and BMI,SUA level was strongly associated with fasting glucose in the IFG group(r=0.534,P<0.001).After further adjustment for blood lipid and blood pressure,the correlation persisted(r=0.523,P<0.001).With Q1 as the control group,the calculated OR values of IFG risk were 1.199,2.660,2.784 and 3.629,respectively.After further adjustment for various confounding factors,the calculated OR values of each group were 1.130,2.389,2.350 and 2.895,respectively.The IFG risk in the group with SUA level in the corresponding Q2 and Q5 groups was 1.13 times and 2.90 times higher,respectively,than that in the normal group,indicating that with the increase in SUA level,the IFG risk in the population increased.With the increase in BMI and SUA levels after BMI stratification,the mean fasting glucose level increased(P<0.001).Conclusion The SUA level and IFG risk are closely related.Increased SUA level increases IFG risk,and SUA and IFG are associated with weight gain,which should be paid attention to.
作者
张彤
张梦千
彭方书
李凤
翁晓峰
沈振海
陆昀
沈史伟
Zhang Tong;Zhang Mengqian;Peng Fangshu;Li Feng;Weng Xiaofeng;Shen Zhenhai;Lu Yun;Shen Shiwei(Recuperation and Rehabilitation Center,Taihu Sanatorium of Jiangsu Province,Wuxi 214086,China;Department of Laboratory,Taihu Sanatorium of Jiangsu Province,Wuxi 214086,China;Jiangsu Provincial Research Center for Health Assessment and Intervention,Wuxi 214086,China;Department of Endocrinology,Wuxi Second Hospital Affiliated to Nanjing Medical University,Wuxi 214002,China)
出处
《中华健康管理学杂志》
CAS
CSCD
2021年第6期562-566,共5页
Chinese Journal of Health Management
关键词
尿酸
高尿酸血症
空腹血糖受损
体质指数
糖尿病
2型
Uric acid
Hyperuricemia
Impaired fasting glucose
Body mass index
Diabetes mellitus,type 2
