摘要
目的评价加味四逆散联合穴位贴敷治疗腹泻型肠易激综合征(IBS-D)肝郁脾虚证临床疗效。方法将符合标准的2018年10月-2020年12月本院104例IBS-D肝郁脾虚证患者按随机数字表法分为2组,每组52例。2组均先口服蒙脱石散,在此基础上对照组加用匹维溴铵片,研究组给予加味四逆散联合穴位贴敷治疗。2组均治疗4周。分别于治疗前后进行中医症状评分,采用ELISA法检测血清IL-6、IL-8、TNF-α水平,观察并记录患者大便性状恢复正常时间、腹痛消失时间、大便次数恢复正常时间,评价临床疗效。结果观察组总有效率为92.3%(48/52)、对照组为75.0%(39/52),2组比较差异有统计学意义(χ^(2)=5.696,P=0.017)。治疗后,观察组腹痛、腹泻、大便次数多、烦躁易怒、神疲乏力、胁肋胀痛评分低于对照组(t值分别为15.492、16.827、13.419、10.831、14.736、12.437,P值均<0.001),血清IL-6、IL-8、TNF-α水平低于对照组(t值分别为16.390、21.528、18.734,P值均<0.001)。观察组大便性状恢复正常时间[(3.79±0.63)d比(4.84±0.79)d,t=7.493]、腹痛消失时间[(2.63±0.32)d比(3.91±0.37)d,t=18.869]、大便次数恢复正常时间[(3.26±0.57)d比(4.19±0.68)d,t=7.558]较对照组明显缩短(P<0.01)。结论加味四逆散联合穴位贴敷可有效改善IBS-D肝郁脾虚证患者的临床症状,降低血清炎性细胞因子水平,提高疗效。
Objective To evaluate the clinical efficacy of modified Sini Powder combined with acupoint application in the treatment of liver depression and spleen deficiency syndrome of diarrhea irritable bowel syndrome(IBS-D).Methods A total of 104 IBS-D patients with liver depression and spleen deficiency syndrome in our hospital from October 2018 to December 2020 were randomly divided into two groups according to the random number table method,52 in each group.Both groups took montmorillonite powder orally first.On this basis,the control group was treated with pivirium bromide tablets,and the study group was treated with Modified Sini Powder combined with acupoint application.Both groups were treated for 4 weeks.TCM symptom scores were performed before and after treatment.The levels of serum IL-6,IL-8 and TNF-awere detected by ELISA.The recovery time of stool characteristics,the disappearance time of abdominal pain and the recovery time of stool times were observed and recorded,and the clinical curative effect was evaluated.Results The total effective rate was 92.3%(48/52)in the observation group and 75.0%(39/52)in the control group,there was significant difference between the two groups(χ^(2)=5.696,P=0.017).After treatment,the scores of abdominal pain,diarrhea,stool frequency,irritability,mental fatigue and hypochondriac pain in the observation group were significantly lower than those in the control group(t values were 15.492,16.827,13.419,10.831,14.736,12.437,respectively,all Ps<0.001),and the levels of serum IL-6,IL-8 and TNF-a were significantly lower than those in the control group(t values were 16.390,21.528 and 18.734,respectively,all Ps<0.001).The recovery time of stool characteristics[(3.79±0.63)d vs.(4.84±0.79)d,t=7.493],the disappearance time of abdominal pain[(2.63±0.32)d vs.(3.91±0.37)d,t=18.869],and the recovery time of stool times[(3.26±0.57)d vs.(4.19±0.68)d,t=7.558]in the observation group were significantly shorter than those in the control group(P<0.01).Conclusion Modified Sini Powder combined with acupoint application can improve the clinical symptoms of IBS-D patients with liver depression and spleen deficiency syndrome,reduce the level of serum inflammatory cytokines and improve the curative effect.
作者
司敏
刘万里
孙刚
Si Min;Liu Wanli;Sun Gang(Department of Spleen and Stomach,Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing 210000,China)
出处
《国际中医中药杂志》
2021年第12期1194-1198,共5页
International Journal of Traditional Chinese Medicine
基金
江苏省“六大人才高峰”项目(2016-WSN-207)
南京市卫生科技发展专项资金项目(YKK20161)。
关键词
肠易激综合征
肝郁脾虚证
加味四逆散
穴位贴敷疗法
Irritable bowel syndrome
Liver depression and spleen deficiency syndrome
Modified Sini Powder
Acupoint application therapy
