摘要
中医药治疗恶性肿瘤在整体观指导下辨证论治,具有切实有效、无明显副作用、经济实惠等特点,越来越受到重视。蛋白质组学是基于蛋白质分离技术、质谱鉴定技术和生物信息技术对基因所表达的全部蛋白质功能、结构、相互作用进行研究的学说,其整体性和动态性等技术特点与中医学的整体思维和辨证施治相符合。本文就近年来蛋白质组学在探究恶性肿瘤证候本质研究及揭示中医药防治作用靶点方面的应用展开综述,以期为拓展中医药防治恶性肿瘤研究提供思路。
Under the guidance of holistic view, traditional Chinese medicine(TCM) treatment of malignant tumors based on syndrome differentiation has the advantages of being practical and effective,without obvious side effects, and having obvious economic benefits. Proteomics refers to the study of the function, structure and interaction of all proteins expressed by genes by using protein separation technology, mass spectrometry identification technology and bioinformatics. The integrity and dynamic technical characteristics of proteomics are consistent with the holistic thinking and syndrome differentiation of traditional Chinese medicine. This paper reviewed the application of proteomics in exploring the syndrome essence of malignant tumor and revealing the target of TCM prevention and treatment in recent years,so as to provide ideas for expanding the research of TCM prevention and treatment of malignant tumors.
作者
邓海滨
王中奇
蔡玥娇
胡紫洁
张铭
龚亚斌
鲁叶云
徐振晔
DENG Hai-bin;WANG Zhong-qi;CAI Yue-jiao;HU Zi-jie;ZHANG Ming;GONG Ya-bin;LU Ye-yun;XU Zhen-ye(Department of Oncology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Department of Integrated Traditional Chinese and Western Medicine,ShanghaiChest Hospital,Shanghai Jiao Tong University,Shanghai 200030,China;Department of Oncology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Department of Traditional Chinese Medicine Internal Medicine,Chongming Branch of Shanghai Tenth People’s Hospital,Shanghai 202159,China)
出处
《中医肿瘤学杂志》
2022年第1期36-42,共7页
Journal of Oncology in Chinese Medicine
基金
上海市教育委员会科研创新计划重大项目(编号:2017-01-07-00-10-E00064)
上海市中医药领军人才培养计划[编号:ZY(2018-2020)-RCPY-1001]。
关键词
蛋白质组学
中医药
恶性肿瘤
proteomics
traditional Chinese medicine
malignant tumors
