摘要
目的总结肥胖与甲状腺癌的关系及分子机制研究的最新进展。方法以“肥胖”“甲状腺癌”“促甲状腺激素”“脂肪因子”“胰岛素抵抗”“脂联素”及“obesity”“thyroid cancer”“thyroid stimulating hormone”“adipokines”“insulin resistance”“adiponectin”等作为中英文关键词在中国知网、万方数据库以及PubMed等中英文数据库中检索2021年之前发表的肥胖与甲状腺癌关系及分子机制的相关文献共901篇,剔除与内容不符、无法获得全文、重复性研究的文献,对最终纳入的37篇文献进行总结和分析。结果流行病学方面的研究已证实,肥胖是甲状腺癌发病的风险因素。近些年研究结果表明,肥胖与甲状腺癌的临床不良病理特征存在相互关联性。肥胖与甲状腺癌预后方面的关系存在争议,其原因可能与随访时间的长短以及甲状腺癌外科干预的预后情况等有关。肥胖与甲状腺癌发生、发展的相关分子机制,目前仍存在较大争议,需进一步研究。结论肥胖是甲状腺癌发病的重要风险因素,并且与甲状腺癌的不良临床病理因素相关,但肥胖与甲状腺癌预后的关系,以及肥胖与甲状腺癌发病的具体相关分子机制尚不明确,仍需进一步深入研究。
Objective To summarize the latest advances in the study on the relationship between obesity and thyroid cancer and its molecular mechanism.Methods Chinese and English databases,such as CNKI,Wanfang,and PubMed,were searched by using Chinese and English keywords,such as"肥胖""甲状腺癌""促甲状腺激素""脂肪因子""胰岛素抵抗""脂联素"and"obesity""thyroid cancer""thyroid stimulating hormone""adipokines""insulin resistance""adiponectin",for 901 articles published before 2021 regarding the relationship between obesity and thyroid cancer and its molecular mechanism.The final 37 papers were summarized and analyzed by eliminating the papers that were not in accordance with the content,had unavailable full text,and were repeated.Results Epidemiological studies have confirmed that obesity is a risk factor for thyroid cancer.Recent studies have shown a correlation between obesity and the clinicopathologic features of thyroid cancer.The relationship between obesity and the prognosis of thyroid cancer is controversial,and the reasons may be related to the length of follow-up time and the prognosis of surgical intervention for thyroid cancer.The molecular mechanism of obesity and the occurrence and development of thyroid cancer remains controversial and needs to be further studied.Conclusions Obesity is an important risk factor for thyroid cancer and is associated with the adverse clinicopathological factors of thyroid cancer.However,the relationship between obesity and the prognosis of thyroid cancer and the specific molecular mechanisms of obesity and the incidence of thyroid cancer are still unclear,which need to be studied further.
作者
周政
许世莹
王佳峰
Zhou Zheng;Xu Shiying;Wang Jiafeng(Bengbu Medical College Graduate School,Bengbu 233030,China;Department of Head and Neck Surgery,Center of Otolaryngology-Head and Neck Surgery,Zhejiang Provincial People's Hospital,People's Hospital of Hangzhou Medical College,Hangzhou 310014,China;Zhejiang Provincial Key Laboratory of Diagnosis and Treatment of Endocrine Gland Diseases,Hangzhou 310014,China)
出处
《中华解剖与临床杂志》
2022年第1期60-64,共5页
Chinese Journal of Anatomy and Clinics
基金
浙江省医药卫生科学研究基金(2021424557)
浙江省中医药科技计划(2021ZA008)。
