摘要
目的:观察益气活血方治疗非ST段抬高型心肌梗死(non-ST-segment elevation myocardial infarction,NSTEMI)并发心源性晕厥患者的临床疗效。方法:70例NSTEMI并发心源性晕厥患者按随机数字表法随机分为对照组和观察组。对照组给予常规西医治疗;观察组在对照组治疗基础上给予益气活血方,两组均治疗4周。比较两组患者临床疗效、心功能以及血流动力学。心功能指标:左室射血分数(left ventricular ejection fraction,LVEF)、室壁节段运动指数(ventricular segmental motion index,WMSI)及心脏舒张期血流速度E与A峰比值(diastolic blood flow velocity E to A peak ratio,E/A);心肌酶指标:血清肌酸激酶同工酶(serum creatine kinase isoforms enzymes,CK-MB)、心肌肌钙蛋白(cardiac troponin,cTnI)及磷脂酶A2(phospholipase A2,LP-PLA2);血流动力学指标:血小板聚集率(platelet aggregation rate,PAG)、外周血管阻力指数(peripheral vascular resistance index,SVRI)、血管外肺水指数(extravascular lung water index,ELWI)及平均动脉压(mean arterial pressure,MAP)。结果:观察组心电图监测有效率为94.29%,高于对照组的65.71%,差异有统计学意义(P<0.05)。治疗后,观察组心胸刺痛、头晕目眩、气短乏力、黑蒙评分低于对照组,LVEF、E/A高于对照组,WMSI低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组CK-MB、cTnI、LP-PLA2表达低于对照组,PAG、ELWI低于对照组,SVRI、MAP高于对照组,差异均有统计学意义(P<0.05)。观察组主要终点事件发生率为2.86%,低于对照组的20.0%,差异有统计学意义(P<0.05)。结论:益气活血方治疗NSTEMI并发心源性晕厥患者疗效显著,可改善患者心功能,改善血流动力学。
Objective:To analyze the therapeutic effect of Yi Qi Huo Xue Recipe on patients with non-ST-segment elevation myocardial infarction complicated by cardiogenic syncope.Methods:A total of 70 patients with NSTEMI complicated with cardiogenic syncope were divided into control group and observation group according to a random number table.The control group was given conventional western medicine treatment;the observation group was given Yi Qi Huo Xue prescription on the basis of the treatment of the control group.Both groups were treated for 4 weeks.The treatment effects,cardiac function,and hemodynamic changes between the two groups were compared.Cardiac function indicators:left ventricular ejection fraction(LVEF),ventricular segmental motion index(WMSI)and diastolic blood flow velocity E to A peak ratio(E/A);myocardial enzyme indicators:serum creatine kinase isoforms Enzymes(CK-MB),cardiac troponin(cTnI)and phospholipase A2(LP-PLA2);hemodynamic indicators:platelet aggregation rate(PAG),peripheral vascular resistance index(SVRI),extravascular lung water Index(ELWI)and mean arterial pressure(MAP).Results:The effective rate of ECG monitoring in the observation group was 94.29%,which was higher than 65.71%in the control group.The difference was statistically significant(P<0.05).After 4 weeks of treatment,the scores of chest pain,dizziness,shortness of breath,weakness,and amaurosis in the observation group were lower than those in the control group,LVEF and E/a were higher than those in the control group,WMSI was lower than those in the control group,and the difference was statistically significant(P<0.05).After the treatment,the expression of CK-MB,cTnI,Lp-PLA2 in the observation group was lower than that in the control group,PAG,ELWI were lower than those in the control group,SVRI,MAP was higher than those in the control group,and the difference was statistically significant(P<0.05).The incidence of primary endpoint events in the observation group was 2.86%,which was lower than 20.0%in the control group,and the difference was statistically significant(P<0.05).Conclusion:Yi Qi Huo Xue Recipe has a significant curative effect in the treatment of patients with NSTEMI complicated by cardiogenic syncope,which can improve the heart function and hemodynamics of the patients.
作者
曹云艳
CAO Yunyan(Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou Henan China 450000)
出处
《中医学报》
CAS
2022年第2期402-407,共6页
Acta Chinese Medicine
基金
河南省高等学校重点科研计划项目(20A360007)。
关键词
心肌梗死
心源性晕厥
益气活血方
心功能
血流动力学
myocardial infarction
cardiogenic syncope
Yi Qi Huo Xue Recipe
cardiac function
hemodynamics
