摘要
目的分析导致替加环素引发凝血功能异常的相关危险因素。方法收集本院2019年1月至12月接受替加环素治疗的感染性疾病患者病例资料,分为研究组(凝血功能异常)和对照组(未发生凝血功能异常)。比较2组患者在性别、年龄、肝功能、肾功能、凝血功能、替加环素用法用量、合并用药等因素上的差异,对存在显著差异的指标进行单因素和多因素Logistic回归分析,以获得独立危险因素。结果共纳入119例患者,研究组29例,对照组90例,2组在合并休克(χ^(2)=5.540,P=0.019)、接受重大手术(χ^(2)=10.194,P=0.001)、合并肾功能不全(χ^(2)=5.903,P=0.015)、用药前白细胞计数(WBC)(t=-2.748,P=0.007)、用药前凝血酶原时间(PT)(t=-4.868,P=0.000)、高剂量替加环素(χ^(2)=4.214,P=0.000)、替加环素用药时间(t=-3.197,P=0.002)及合并使用两种及以上抗菌药(χ^(2)=4.712,P=0.030)方面有显著差异。对上述指标进行多因素Logistic回归分析,发现替加环素用药前PT(OR=4.283,P=0.007)、用药时间(OR=2.892,P=0.011)、高剂量(OR=5.661,P=0.028)可能是导致患者凝血功能异常的独立危险因素。结论用药前PT长及替加环素高剂量、长疗程用药可能与其导致凝血功能异常相关,临床应予以重视。
AIM To analyze the relative factors of blood coagulation abnormality in patients treated with tigecycline.METHODS Data of patients with infectious diseases treated by tigecycline in our hospital from January 2019 to December 2019 were collected and divided into study group(with blood coagulation abnormality)and control group(without blood coagulation abnormality).The differences in sex,age,liver and renal function,coagulation function,dosage and duration of tigecycline,combined medication and other factors were compared between the two groups.Univariate and multivariate logistic regression analysis were performed on the statistically significant indicators to analyze relative factors for blood coagulation abnormality induced by tigecycline.RESULTS A total of 119 patients were enrolled,29 in the study group and 90 in the control group.There were statistically differences between the two groups in combined shock(χ^(2)=5.540,P=0.019),major surgery(χ^(2)=10.194,P=0.001),renal failure(χ^(2)=5.903,P=0.015),white blood cell count before treatment(t=-2.748,P=0.007),prothrombin time(PT)before treatment(t=-4.868,P=0.000),high dosage of tigecycline(χ^(2)=4.214,P=0.000),medication time of tigecycline(t=-3.197,P=0.002)and combined with two or more antibacterial drugs(χ^(2)=4.712,P=0.030).Multivariate logistic regression analysis showed that PT before treatment(OR=4.283,P=0.007),medication time of tigecycline(OR=2.892,P=0.011)and high dosage(OR=5.661,P=0.028)were independent risk factors for blood coagulation abnormality caused by tigecycline.CONCLUSION The long PT before treatment,high dosage and long course of treatment may be the causes of abnormal coagulation function caused by tigecycline which should be paid attention to clinically.
作者
杨钰华
李静
宋惠珠
马红燕
黄元
钱正月
YANG Yu-hua;LI Jing;SONG Hui-zhu;MA Hong-yan;HUANG Yuan;QIAN Zheng-yue(Wuxi People’s Hospital,Nanjing Medical University,Wuxi JIANGSU 214023,China)
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2022年第1期52-56,共5页
Chinese Journal of New Drugs and Clinical Remedies
基金
江苏省医院协会医院管理创新研究课题(JSYGY-3-2019-34)。
关键词
替加环素
凝血功能异常
因素分析
统计学
药物不良反应
tigecycline
blood coagulation abnormality
factor analysis,statistical
adverse drug reactions
