摘要
骨骼正常发育和稳态维持是人体正常行使功能的重要前提,如果出现骨骼发育畸形或者稳态紊乱,如颅缝早闭、腭裂、大骨节病和骨关节炎等,对患者个人的生活,甚至家庭、社会都造成重大影响。成纤维细胞生长因子8(fibroblast growth factor 8,FGF8)在生物体整个生命历程中发挥着许多功能。FGF8的表达异常可能会导致骨骼稳态紊乱和发育畸形。研究表明FGF8在骨骼发育中发挥重要作用,并有可能作为靶标发挥治疗功能。本综述针对FGF8在多种骨骼异常疾病中的作用进行总结,以期为今后相关疾病的防治开拓新的视野。
The proper development and the homeostasis maintenance of bones are important prerequisites for the normal functioning of the human body.Bone developmental deformities or homeostasis disorders,such as Kashin-Beck disease,craniosynostosis,cleft palate and osteoarthritis,severely affect the life of patients,causing significant stress to the family and the society.Fibroblast growth factor 8(FGF8)plays multiple functions through the course of the life of organisms.Abnormal expression of FGF8 may cause disorders of bone homeostasis and developmental abnormalities of bones.More and more studies have found that FGF8 may play an important role in bone development and may become a potential therapeutic target.Herein,we reviewed the role of FGF8 in a variety of skeletal abnormalities,intending to provide new perspectives for the prevention and treatment of related diseases in the future.
作者
黄宏灿
魏洁雅
张德茂
周学东
HUANG Hong-can;WEI Jie-ya;ZHANG De-mao;ZHOU Xue-dong(State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,and Department of Dental and Endodontic Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2022年第1期54-57,共4页
Journal of Sichuan University(Medical Sciences)
基金
国家自然科学基金(No.81670978、No.81870754)资助。
关键词
成纤维细胞生长因子8
颅缝早闭
腭裂
骨关节炎
大骨节病
Fibroblast growth factor 8
Craniosynostosis
Cleft palate
Osteoarthritis
Kashin-Beck disease
