摘要
透明质酸(Hyaluronic acid,HA)是细胞外基质的重要组成成分,具有生物相容性、无毒性、非免疫原性和良好的生物降解性等特性。HA及其衍生物常作为药物靶向载体和3D生物打印的原材料用于药物的传递和筛选,并延长药物作用时间和半衰期。本文综述了HA在载药、靶向给药和药物筛选中的应用,为HA及其衍生物在临床中的应用提供参考。
Hyaluronic acid(HA)is an important component of extracellular matrix(ECM),which has biodegradability,biocompatibility,non-toxicity,non-immunogenicity and other benign physicochemical properties. HA and its derivatives,as drug targeting carriers and raw materials for 3 D bio-printing,are used for drug delivery and screening,and prolonging the action time and half-life of drugs. The application of hyaluronic acid in drug delivery,drug targeting and drug screening were reviewed,so as to provide reference for the clinical application of HA and its derivatives.
作者
赵玥
程禄萍
谢保平
ZHAO Yue;CHENG Lu-ping;XIE Bao-ping(School of Pharmacy,Gannan Medical University;Key Laboratory of Ministry of Education for Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases,Gannan Medical University,Ganzhou,Jiangxi 341000)
出处
《赣南医学院学报》
2021年第12期1277-1281,1284,共6页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
基金
江西省教育厅项目(GJJ180809)
赣南医学院校级课题(YB201901)
赣南医学院心脑血管疾病防治教育部重点实验室开放基金课题(XN202025)。
