摘要
目的 探讨苍附导痰汤加减对多囊卵巢综合征(PCOS)患者visfatin水平及胰岛素抵抗的影响。方法 选择2018年1月至2020年1月至浙江省中西医结合医院中医妇科门诊60例符合纳入标准年龄在20~40岁的PCOS患者,用随机数字表法分为对照组和治疗组各30例。对照组予二甲双胍片餐中口服500 mg每日2次,治疗组月经第5天起每日分两次口服苍附导痰汤加减100 ml,至下次月经来潮,同时口服二甲双胍同对照组,两组均服用药物3个月经周期,治疗前后均测定患者胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(ISI)、血浆visfatin水平。结果 两组组内治疗前后HOMA-IR比较,对照组治疗后(1.655±0.359)低于治疗前(2.022±0.346),治疗组治疗后(1.493±0.136)低于治疗前(2.260±0.502),差异均有极其显著的统计学意义(P<0.001);治疗后,治疗组HOMAIR低于对照组,差异有统计学意义(P<0.05)。两组组内治疗前后ISI比较,对照组治疗后为(0.028±0.002),高于治疗前为(0.022±0.004),治疗组治疗后为(0.030±0.002),高于治疗前的(0.020±0.004),差异均有极其显著的统计学意义(P<0.001);治疗后,治疗组ISI高于对照组,差异有统计学意义(P<0.05)。两组治疗前后visfatin比较,对照组治疗后为(1.024±0.602) ng/ml,低于治疗前的(1.605±1.300) ng/ml,治疗组治疗后为(0.662±0.405) ng/ml,低于治疗前的(1.522±1.080) ng/ml,差异均有统计学意义(P<0.05,P<0.001);治疗后,治疗组visfatin低于对照组,差异有统计学意义(P<0.05)。结论 苍附导痰汤加减可以有效改善多囊卵巢综合征患者visfatin水平及胰岛素抵抗。
Objective To investigate the effect of Cangfudaotan Decoction on the level of visfatin and insulin resistance in patients with polycystic ovary syndrome.Methods From January 2018 to January 2020,60 patients who met the inclusion criteria between the ages of 20 and 40 from the Department of Traditional Chinese Medicine and Gynecology in the Integrated Chinese and Western Medicine Hospital of Zhejiang Province were selected and randomly divided into the western medicine control group and the traditional Chinese and western medicine treatment group,with 30 patients in each group.The control group was given western medicine with metformin tablets orally 500 mg twice a day.The treatment group was given oral Cangfudaotan Decoction Plus-Minus 100 ml twice a day and metformin the same as the control group from the fifth day of menstruation until the next menstrual cramps.Both groups took the drug for three menstrual cycles.The patients'insulin resistance index(HOMA-IR),insulin sensitivity index(ISI),and plasma visfatin levels were measured before and after treatment.Results The HOMA-IR result before treatment in the control group was(2.022±0.346),which was higher than that of(1.655±0.359)after treatment.The HOMA-IR result before treatment in the treatment group was(2.260±0.502),which was higher than that of(1.493±0.136)after treatment.The difference before and after treatment in two groups was extremely statistically significant(P<0.001).The HOMA-IR after treatment in the treatment group was lower than that in the control group,and the difference was statistically significant(P<0.05).The ISI result of the control group before treatment was(0.022±0.004),which was lower than that of(0.028±0.002)after treatment.The ISI result before treatment in the treatment group was(0.020±0.004),which was lower than that of(0.030±0.002)after treatment,and the difference between the two groups before and after treatment was extremely statistically significant(P<0.001).The ISI after treatment in the treatment group was higher than that in the control group,and the difference was statistically significant(P<0.05).The visfatin result before treatment in the control group was(1.605±1.300)ng/ml,which was higher than that of(1.024±0.602)ng/ml after treatment.The visfatin result of the treatment group before treatment was(1.522±1.080)ng/ml,which was higher than(0.662±0.405)ng/ml after treatment.The difference between the two groups before and after treatment was statistically significant(P<0.05,P<0.001).The visfatin after treatment in the treatment group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Cangfudaotan Decoction can effectively improve visfatin level and insulin resistance in patients with polycystic ovary syndrome.
作者
万凌屹
杨岳
苗润泽
丁彩飞
WAN Lingyi;YANG Yue;MIAO Runze;DING Caifei(Department of Traditional Chinese Medicine and Gynecology,Integrated Chinese and Western Medicine Hospital of Zhejiang Province,Hangzhou310003,China)
出处
《中国现代医生》
2022年第1期153-156,共4页
China Modern Doctor
基金
浙江省中医药科技计划(2018ZA096)。
