摘要
中医认为,脾乃后天之本,气血生化之源,若脾失健运,运化失司,则出现腹胀、肠鸣、泄泻等症状,与现代医学胃肠、免疫、代谢等疾病密切相关。肠道菌群作为与机体长期共生的微生物系统,在抵御病原入侵、保护胃肠、恢复免疫等一系列病理生理过程中发挥重要作用。近年研究表明,肠道菌群紊乱可看作中医"脾失健运"病理体现,健脾类中药及其组分可通过调节肠道菌群改善其相关病理,尤其多糖是发挥功能的主要活性成分。本文对健脾类中药多糖组分调节肠道菌群的相关作用及可能机制进行综述,可为改善脾虚相关疾病的进一步研究及临床应用提供参考。
TCM believes that the spleen is the acquired foundation and the source of qi and blood.If the spleen functions disorderly,there will be abdominal distension,intestinal singing,diarrhea and other symptoms,which are often closely related to gastrointestinal,immune and metabolic diseases.As a microflora that has long coexisted with the body,intestinal flora plays a vital role in a series of pathophysiological processes such as resisting pathogen invasion,protecting the gastrointestinal tract and restoring immunity.In recent years,most studies have shown that intestinal flora disorders can be regarded as one of the pathological manifestations of TCM“dysfunction spleen in transportation”.Spleen-invigorating TCM and their components can improve the related pathology by regulating the intestinal flora,and especially polysaccharides are the main active ingredients that exert their functions.Therefore,this article reviewed the related effects and possible mechanisms of the polysaccharide components of spleen-invigorating TCM in regulating intestinal flora,which can provide references for further research and clinical application in improving spleen deficiency-related diseases.
作者
张洪源
任广振
黄建政
王鹏源
刘威豪
汤凯璇
赵文晓
ZHANG Hongyuan;REN Guangzhen;HUANG Jianzheng;WANG Pengyuan;LIU Weihao;TANG Kaixuan;ZHAO Wenxiao(Shandong University of Traditional Chinese Medicine,Jinan 250355,China)
出处
《中国中医药信息杂志》
CAS
CSCD
2022年第2期147-151,共5页
Chinese Journal of Information on Traditional Chinese Medicine
基金
国家自然科学基金(81903947)
山东省重点研发计划(2019GSF108209)
山东省大学生创新创业训练计划(S202010441027)。
关键词
脾虚
中药多糖
肠道菌群
健脾中药
spleen deficiency
TCM polysaccharides
intestinal flora
spleen-invigorating TCM
