摘要
胰腺癌是一种预后极差的消化系统恶性肿瘤,代谢重编程是胰腺癌的显著特征之一。胰腺癌中最常见的KRAS基因突变通过一系列信号通路调控支链氨基酸代谢发生特异性改变。支链氨基酸转氨酶和支链酮酸脱氢酶等支链氨基酸代谢酶的异常表达在胰腺癌的发生和发展中发挥重要作用。循环支链氨基酸浓度的异常升高可以作为胰腺癌早期诊断的重要标志物。本文对胰腺癌与支链氨基酸代谢重编程的研究进展进行总结,阐述支链氨基酸代谢在胰腺癌中的临床转化和应用。
Pancreatic cancer is a malignant tumor of digestive system with dismal prognosis.Metabolic reprogramming is one of the prominent features of pancreatic cancer.Mutations in KRAS gene are the most common in pancreatic cancer,resulting in aberrant regulation of branched-chain amino acid(BCAA)metabolism,and BCAA metabolic enzymes such as BCAT2 and branched-chainα-keto acid dehydrogenase kinase(BCKDH)play a role in the occurrence and development of pancreatic cancer.As an early event in the development of pancreatic cancer,the increased circulating BCAA can be a marker for early diagnosis of pancreatic cancer.This review summarizes recent researches on BCAA metabolism reprogramming in pancreatic cancer,and describes the clinical translation of BCAA metabolism in pancreatic cancer.
作者
刘珂
刘颖斌
LIU Ke;LIU Yingbin(Department of Biliary and Pancreatic Surgery,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Institute of Biliary Tract Disease,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;State Key Laboratory of Oncogenes and Related Genes,Shanghai 200127,China)
出处
《肿瘤》
CAS
CSCD
北大核心
2021年第12期876-880,共5页
Tumor
基金
国家自然科学基金(81874181)。
关键词
胰腺癌
支链氨基酸代谢
代谢重编程
基因突变
肿瘤微环境
Pancreatic carcinoma
Branched-chain amino acid metabolism
Metabolic reprogramming
Gene mutation
Tumor microenvironment
