摘要
目的:研究缺血性脑卒中溶栓治疗前后患者血清钙调蛋白(CAM)、血栓素B;(TXB_(2))、氧化型低密度脂蛋白(ox-LDL)水平变化及其与神经功能的相关性。方法:选取2018年10月-2021年2月恩施市中心医院收治的80例缺血性脑卒中患者为观察组,另选取80例同期体检健康者为对照组。观察组给予溶栓治疗,比较两组血清CAM、TXB_(2)、ox-LDL水平变化,采用美国国立卫生研究院卒中量表评分(NIHSS评分)评估观察组神经功能缺损程度,并分析其与血清CAM、TXB_(2)、ox-LDL水平的相关性。结果:观察组治疗前血清CAM、TXB_(2)、ox-LDL水平均高于对照组,差异均有统计学意义(P<0.05)。观察组治疗后1周血清CAM、TXB_(2)、ox-LDL水平均低于治疗前,但观察组血清CAM、TXB_(2)、ox-LDL水平高于对照组,差异均有统计学意义(P<0.05)。治疗后1周,观察组NIHSS评分低于治疗前,差异有统计学意义(P<0.05)。Pearson相关性分析显示,缺血性脑卒中患者治疗后1周的CAM、TXB_(2)、ox-LDL水平与NIHSS评分呈正相关(r=0.868、0.872、0.851,P<0.05)。结论:血清CAM、TXB_(2)、ox-LDL水平在缺血性脑卒中明显增高,且与NIHSS评分均呈正相关,可作为判断病情严重程度的重要指标。
Objective:To study the changes of serum calmodulin(CAM),thromboxane B;(TXB_(2)) and oxidized low density lipoprotein(ox-LDL)levels in patients with ischemic stroke before and after thrombolytic therapy,and their correlation with neurological function.Method:A total of 80 patients with ischemic stroke admitted to Enshi Center Hospital from October 2018 to February 2021 were selected as the observation group.Meanwhile,80 healthy individuals were selected as the control group.The observation group was given thrombolytic therapy.Serum levels of CAM,TXB_(2) and ox-LDL were compared between two groups.National Institutes of Health stroke scale score(NIHSS score)was used to evaluate the degree of neurological function impairment in the observation group,and its correlation with serum CAM,TXB_(2)and ox-LDL levels was analyzed.Result:Before treatment,serum CAM,TXB_(2) and ox-LDL levels in the observation group were higher than those in the control group(P<0.05).1 week after treatment,the serum CAM,TXB_(2) and ox-LDL levels in the observation group were lower than those before treatment,but the serum CAM,TXB_(2) and ox-LDL levels in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).1 week after treatment,NIHSS score of the observation group was lower than that before treatment,the difference was statistically significant(P<0.05).Pearson correlation analysis showed that CAM,TXB_(2)and ox-LDL levels were positively correlated with NIHSS score 1 week after treatment(r=0.868,0.872,0.851,P<0.05).Conclusion:The levels of serum CAM,TXB_(2)and ox-LDL are significantly increased in patients with ischemic stroke,and they are positively correlated with NIHSS score.They can be used as important indicators to judge the severity of disease.
作者
张金龙
张雪芹
孙战风
ZHANG Jinlong;ZHANG Xueqin;SUN Zhanfeng(Enshi Center Hospital,Enshi 445000,China;不详)
出处
《中外医学研究》
2022年第3期135-138,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
