摘要
目的:探究表皮生长因子受体(EGFR)敏感突变晚期非小细胞肺癌(NSCLC)患者应用盐酸埃克替尼靶向治疗对患者神经钙黏素表达的干预。方法:选取2015年4月~2018年7月某院收治的EGFR敏感突变晚期NSCLC患者80例,根据治疗方式不同,将其分为观察组和对照组各40例,对照组给予吉非替尼,观察组采用盐酸埃克替尼。治疗8周后,记录两组神经钙黏素mRNA表达量、卡氏(KPS)评分、疾病进展时间与平均生存时间、不良反应。结果:与治疗前比,两组治疗后神经钙黏素mRNA下降,且观察组低于对照组(P<0.01);治疗后两组患者KFS评分明显升高,且观察组明显高于对照组(P<0.01)。观察组平均生存时间较对照组延长(P<0.01)。观察组不良反应发生率为55.00%,低于对照组的77.50%(P<0.05)。结论:盐酸埃克替尼可以降低EGFR敏感突变晚期NSCLC患者神经钙黏素mRNA的表达,可以延长患者生存时间,安全性较好。
Objective:To explore the intervention of icotinib hydrochloride targeted therapy in patients with advanced non-small cell lung cancer(NSCLC)and sensitive mutations of epidermal growth factor receptor(EGFR)on N-cadherin expression.Methods:Eighty patients with advanced NSCLC and EGFR-sensitive mutations admitted to a hospital were selected and divided into an observation group(n=40)and a control group(n=40)according to the random number table method.The control group was given gefitinib,and the observation group was given icotinib hydrochloride.After 8 weeks of treatment,the expression of N-cadherin mRNA,KPS score,disease progression time,average survival time,and adverse reactions were recorded in the two groups.Results:Compared with before treatment,the N-cadherin mRNA of the two groups was decreased after treatment,and the observation group was lower than the control group(P<0.01).After treatment,the KFS scores of the two groups were significantly increased,and the observation group was significantly higher than the control group(P<0.01).The average survival time of the observation group was longer than that of the control group(P<0.01).The incidence of adverse reactions in the observation group was 55.00%,which was lower than 77.50%in the control group(P<0.05).Conclusion:Icotinib can reduce the expression of N-cadherin mRNA in patients with advanced NSCLC and EGFR-sensitive mutations,and can prolong the survival time of patients with better safety.
作者
裴浚淦
Pei Jungan(Department of Medical Oncology,Ruzhou No.1 People's Hospital,Ruzhou 467599)
出处
《数理医药学杂志》
CAS
2022年第2期263-265,共3页
Journal of Mathematical Medicine
