摘要
探讨超声引导下粗针穿刺(US-CNB)组织学检查应用在早期乳腺浸润性小叶癌(ILC)的诊断价值.于2019年10月至2020年10月选择安徽省皖北地区某三甲医院乳腺外科确诊的169例早期乳腺癌患者作为研究对象,术后组织病理学结果(金标准):早期ILC 65例,其他早期乳腺癌患者104例.患者在术前均在超声引导下进行细针穿刺(US-FNAC)与US-CNB组织学检查,与术后病理检查结果进行对比,记录US-FNAC与US-CNB诊断早期ILC价值以及所有患者进行US-CNB检测后雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体-2(HER-2)的阳性表达率.经US-FNAC诊断为早期ILC的患者有46例,其他早期乳腺癌的患者123例.经US-CNB诊断为早期ILC的患者有57例,其他早期乳腺癌的患者112例,US-CNB诊断早期ILC的敏感度84.65%显著高于US-FNAC的68.18%(P<0.05),但两种检测方式的准确度和特异度对比无统计学意义(P>0.05);经US-CNB组织学诊断后,早期ILC患者的HER-2阳性表达率显著高于其他早期乳腺癌患者(P<0.05),ER、PR阳性表达率与其他早期乳腺癌患者对比无统计学意义(P>0.05).US-CNB组织学检查诊断早期ILC的敏感性较好,患者HER-2的阳性表达率高.
Objective To analyze the value of ultrasound-guided thick needle aspiration(US-CNB)histological examination in the diagnosis of early invasive lobular carcinoma(ILC)of the breast.Methods 169 patients with early breast cancer diagnosed in the breast surgery department of a third-class hospital in Wanbei,Anhui Province between October 2019 and October 2020 were selected as the research objects.Postoperative histopathological results(gold standard):early breast ILC 65 Cases,104 other early breast cancer patients.All patients underwent ultrasound-guided fine-needle aspiration(US-FNAC)and US-CNB histological examinations before surgery,compared with postoperative pathological examination results,and recorded the value of US-FNAC and US-CNB in the diagnosis of early breast ILC,and all patients Comparison of the positive expression rates of estrogen receptor(ER),progesterone receptor(PR),and human epidermal growth factor receptor-2(HER-2)tested by US-CNB.Results US-FNAC diagnosed 46 patients with early breast ILC and 123 other patients with early breast cancer.US-CNB diagnosed early breast ILC in 57 cases and 112 other early breast cancer patients.The sensitivity of US-CNB in diagnosing early breast ILC was 84.65%higher than that of US-FNAC 68.18%(P<0.05),but The accuracy and specificity of the two detection methods were not statistically significant(P>0.05);the positive expression rate of HER-2 in early breast ILC patients was higher than that in other early breast cancer patients(P<0.05),and the positive expression of ER and PR Compared with other early breast cancer patients,the rate was not statistically significant(P>0.05).Conclusion US-CNB histological examination has good sensitivity in diagnosing early breast ILC,and the positive expression rate of HER-2 in patients is high.
作者
杨波
关静文
YANG Bo;GUAN Jingwen(Department of Pathology, Wanbei Health Vocational College, Suzhou 234000, Anhui China;Department of Pathology, Suzhou Municipal Hospital, Suzhou 234000, Anhui China)
出处
《吉首大学学报（自然科学版）》
CAS
2021年第5期65-69,共5页
Journal of Jishou University(Natural Sciences Edition)
关键词
US-CNB组织学
早期乳腺浸润性小叶癌
诊断价值
US-CNB histological examination
early invasive lobular carcinoma of the breast
diagnostic value
