摘要
目的研究不稳定型心绞痛(UAP)患者外周血中性粒/淋巴细胞比值(NLR)、血清视黄醇结合蛋白(RBP-4)及平均血小板体积(MPV)与其冠状动脉狭窄程度的关系。方法收集2019年1月-2020年1月在天津市北辰医院心内科行冠脉造影检查的214例患者,根据冠脉造影结果分为UAP组142例和冠脉造影正常的对照组72例,UAP组再根据Gensini评分进一步分为轻度病变组(1~30分)58例和重度病变组(≥30分)84例,比较各组外周血白细胞计数(WBC)、中性粒细胞(NC)、淋巴细胞计数(LC)、血小板计数(PLT)、MPV、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及RBP-4,分析NLR、RBP-4及MPV与UAP患者冠脉病变的关系。结果①三组NC、LC、NLR、MPV、HDL-C及RBP-4水平比较,差异有统计学意义(P<0.05);重度病变组和轻度病变组NLR、MPV及RBP-4均高于对照组,LC及HDL-C低于对照组,差异有统计学意义(P<0.05);②多因素Logistic回归分析显示,NLR、RBP-4及MPV是UAP患者冠脉病变严重程度的独立预测因素;③相关性分析显示,NLR、RBP-4及MPV与UAP患者冠脉病变严重程度呈正相关(r=0.515、0.423、0.219,P<0.05)。结论NLR、RBP-4及MPV可反映UAP患者冠脉病变的严重程度,且对冠心病患者的危险分层有重要意义。
Objective To study the relationship between peripheral blood neutrophil/lymphocyte ratio(NLR),serum retinol binding protein 4(RBP-4)and mean platelet volume(MPV)and coronary artery stenosis in patients with unstable angina pectoris(UAP).Methods A total of 214 patients who underwent coronary angiography in the Department of Cardiology,Tianjin Beichen Hospital from January 2019 to January 2020 were collected and divided into UAP group(142 cases)and control group(72 cases)according to the results of coronary angiography.UAP group was further divided into mild lesion group(1-30 scores)and severe lesion group(≥30 scores)according to Gensini scores.The white blood cell count(WBC),neutrophil(NC),lymphocyte count(LC),platelet count(PLT),MPV,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)and RBP-4 in peripheral blood of each group were compared.The relationship between NLR,RBP-4 and MPV and coronary lesions in patients with UAP was analyzed.Results①There were statistically significant differences in NC,LC,NLR,MPV,HDL-C and RBP-4 levels among the three groups(P<0.05).NLR,MPV and RBP-4 in severe lesion group and mild lesion group were higher than those in control group,LC and HDL-C were lower than those in control group,the difference was statistically significant(P<0.05).②Multivariate Logistic regression analysis showed that NLR,RBP-4 and MPV were independent predictors of severity of coronary artery disease in patients with UAP.③Correlation analysis showed that NLR,RBP-4 and MPV were positively correlated with the severity of coronary artery disease in patients with UAP(r=0.515,0.423 and 0.219).Conclusion NLR,RBP-4 and MPV can reflect the severity of coronary lesions in patients with UAP,and have important significance for risk stratification of patients with coronary heart disease.
作者
刘杰
贾志
LIU Jie;JIA Zhi(Department of Cardiology,Tianjin Beichen Hospital,Tianjin 300400,Tianjin,China)
出处
《医学信息》
2022年第3期91-94,共4页
Journal of Medical Information
