摘要
目的:系统评价祛瘀化痰法中药组方治疗非酒精性脂肪性肝病的临床疗效。方法:检索祛瘀化痰法治疗非酒精性脂肪性肝病的随机对照试验文献,进行文献筛选、资料提取及质量分析,使用RevMan 5.3软件对临床有效性、肝功能、血脂、肝/脾CT值等进行Meta分析。结果:最终纳入文献17篇,Meta分析表明,与对照组比较,祛瘀化痰法治疗非酒精性脂肪性肝病临床有效率提高[OR=2.87,95%CI(2.21,3.73),P<0.00001],患者丙氨酸转氨酶(ALT)水平降低[MD=-13.62,95%CI(-18.35,-8.89),P<0.00001],天冬氨酸转氨酶(AST)水平降低[MD=-15.42,95%CI(-20.48,-10.36),P<0.00001],总胆红素降低[MD=-11.07,95%CI(-19.20,-2.94),P=0.008],甘油三酯(TG)降低[MD=-0.53,95%CI(-0.72,-0.34),P<0.00001],总胆固醇(TC)降低[MD=-0.61,95%CI(-0.79,-0.43),P<0.00001],高密度脂蛋白胆固醇(HDL-C)升高[MD=0.19,95%CI(0.09,0.29),P<0.0001],低密度脂蛋白胆固醇(LDL-C)降低[MD=-0.31,95%CI(-0.60,-0.02),P=0.04],肝/脾CT值升高[MD=0.14,95%CI(0.06,0.23),P=0.001]。结论:祛瘀化痰法中药方可改善非酒精性脂肪性肝病患者肝功能、降低血脂,临床有效率高,较单一类型西药治疗有明显优势。
Objective:To systematically evaluate the clinical efficacy of dispelling phlegm and removing stasis methods in the treatment of non-alcoholic fatty liver disease(NAFLD).Methods:Literature on randomized controlled trials(RCTs)of treating NAFLD with dispelling phlegm and removing stasis was searched.The included literature was screened to retrieve data and quality assessment was conducted.In the meta-analysis,RevMan 5.3 was used for evaluating clinical efficacy,liver function,blood lipid levels,and liver-spleen CT number difference.Results:Finally,17 RCTs were included.According to the meta-analysis,compared with the control group the clinical efficacy of treating NAFLD with dispelling phlegm and removing stasis was increased[OR=2.87,95%CI(2.21,3.73),P<0.00001],levels of alanine aminotransferase(ALT)decreased[MD=-13.62,95%CI(-18.35,-8.89),P<0.00001],levels of aspartate transaminase(AST)decreased[MD=-15.42,95%CI(-20.48,-10.36),P<0.00001],levels of total bilirubin(TB)decreased[MD=-11.07,95%CI(-19.20,-2.94),P=0.008],levels of triglyceride(TG)decreased[MD=-0.53,95%CI(-0.72,-0.34),P<0.00001],levels of total cholesterol(TC)decreased[MD=-0.61,95%CI(-0.79,-0.43),P<0.00001],levels of high density lipoprotein cholesterol(HDL-C)increased[MD=0.19,95%CI(0.09,0.29),P<0.0001],levels of low density lipoprotein cholesterol(LDL-C)decreased[MD=-0.31,95%CI(-0.60,-0.02),P=0.04],and liver-spleen CT number difference increased[MD=0.14,95%CI(0.06,0.23),P=0.001].Conclusion:Method of dispelling phlegm and removing blood stasis could improve liver function and reduce blood lipids in patients with NAFLD with high clinical efficacy compared with western medicine.
作者
石皓
邓广辉
李允家
杨梦晗
叶海欣
高磊
SHI Hao;DENG Guanghui;LI Yunjia;YANG Menghan;YE Haixin;GAO Lei(School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China)
出处
《山东中医杂志》
2022年第3期281-289,共9页
Shandong Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(编号:81774170)
广东省杰出青年科学基金项目(编号:2018B030306012)。
关键词
祛瘀化痰
非酒精性脂肪性肝病
META分析
肝功能
血脂
dispelling phlegm and removing blood stasis
non-alcoholic fatty liver disease
meta-analysis
liver function
blood lipid
