摘要
目的探究火疗法对稳定期慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)患者凝血状态及血清一氧化氮(Nitric oxide,NO)、一氧化氮合酶(Nitric oxide synthase,NOS)水平的影响。方法选取2019年1月—2020年1月期间贺州市中医医院收治的90例稳定期COPD患者,按照随机数字表法分为研究组和对照组,每组各45例。对照组患者采用吸氧、祛痰、扩张支气管等传统治疗方法,研究组在对照组基础上给予火疗法。两组患者均连续治疗2周后,观察比较两组患者治疗前后25%潮气量时潮气呼气流速[(Tidal expiratory flow when 25%of tidal volume remained in the lungs,TEF25%)、功能残气量(Functional residual capacity,FRC)、用力呼气最大流速(Peak expiratory flow,PEF)]、凝血状态[活化部分凝血活酶时间(Activated partial thromboplastin time,APTT)、凝血酶原时间(Prothrombin time,PT)、凝血酶时间(Thrombin time,TT)、纤维蛋白原(Fibrinogen,FIB)]、血清NO、NOS水平及临床疗效。结果治疗后研究组总有效率为91.11%(41/45),对照组为75.56%(34/45),两组比较,差异有统计学意义(P<0.05)。治疗后两组患者肺功能PEF、FRC和TEF25%水平均较治疗前升高,差异有统计学意义(P<0.05);且观察组肺功能水平均较对照组明显升高,差异有统计学意义(P<0.05)。治疗后两组患者的凝血功能APTT、PT、TT水平均较治疗前降低,FIB水平较治疗前升高,差异有统计学意义(P<0.05);且观察组APTT、PT、TT水平均较对照组明显降低,FIB水平较对照组明显升高,差异有统计学意义(P<0.05)。治疗后两组患者血清NO、NOS均较治疗前升高,差异有统计学意义(P<0.05);且观察组血清NO、NOS均较对照组明显升高,差异有统计学意义(P<0.05)。结论在临床上,稳定期慢性阻塞性肺疾病患者的治疗效果往往较好,火疗法能够调节稳定期慢性阻塞性肺疾病患者血清NO、NOS水平,缓解高凝状态。
Objective To explore the effects of fire therapy on coagulation status and serum nitric oxide(NO),nitric oxide synthase(NOS)levels in patients with stable chronic obstructive pulmonary disease(COPD).Methods A total of 90 patients with stable COPD who were admitted to Hezhou Hospital of Traditional Chinese Medicine from January 2019 to January 2020 were selected and divided into a study group and a control group according to the random number method,with 45 cases in each group.The patients in the control group were given traditional treatment methods such as oxygen inhalation,expectoration,and bronchial expansion,while the patients in the study group were given fire therapy on the basis of the control group.After continuous treatment for 2 weeks,the tidal expiratory flow rate(Tidal expiratory flow when 25%of tidal volume remained in the lungs,TEF25%),functional residual capacity(Functional residual capacity(FRC),peak expiratory flow(PEF),coagulation status[activated partial thromboplastin time(APTT),prothrombin time(PT),Thrombin time(TT),fibrinogen(FIB)],serum NO,NOS levels and clinical efficacy.of two groups were compared beforeand after treatment.Results After treatment,the total effective rate was 91.11%(41/45)in the study group and 75.56%(34/45)in the control group.There was a statistically significant difference between the two groups(P<0.05).After treatment,the lung levels of functional PEF,FRC and TEF25%were higher than those before treatment,and the difference was statistically significant(P<0.05);and the pulmonary function level of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of APTT,PT and TT in the two groups of patients were lower than those before treatment,and the level of FIB was higher than that before treatment,and the difference was statistically significant(P<0.05);and the levels of APTT,PT,and TT in the observation group were higher than those before treatment).Compared with the control group,the level of FIB was significantly decreased,and the level of FIB was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).And the serum NO and NOS in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Clinically,the treatment effect of patients with stable COPD is often better.Fire therapy can adjust the serum NO and NOS levels in patients with stable COPD and relieve the hypercoagulable state.It is worthy of further promotion and application in clinical practice.
作者
黄世香
黎祥伟
唐峰
邓丽琴
黎海燕
杜美昌
白海燕
HUANG Shi-xiang;LI Xiang-wei;TANG Feng;DENG Li-qin;LI Hai-yan;DU Mei-chang;BAI Hai-yan(Department of Pulmonary Medicine,Hezhou Hospital of Traditional Chinese Medicine,Hezhou Guangxi 542899;Department of Traditional Chinese Medicine,Hezhou Dermatology Hospital,Hezhou Guangxi 542899)
出处
《世界中西医结合杂志》
2022年第1期175-178,183,共5页
World Journal of Integrated Traditional and Western Medicine
基金
广西壮族自治区中医药局自筹经费科研课题(GZZC2019181)。
关键词
稳定期慢性阻塞性肺疾病
火疗法
凝血状态
一氧化氮
一氧化氮合酶
Stable Chronic Obstructive Pulmonary Disease
Fire Therapy
Coagulation Status
Nitric Oxide
Nitric Oxide Synthase
