摘要
夏枯草是唇形科植物夏枯草的干燥果穗,是一种具有多种功能的传统药食两用植物。夏枯草具清肝泻火、明目、散结消肿等功效,其味辛、苦,性寒,归肝、胆经,为常用的清热药,自古便在乳腺疾病的治疗中多有应用。随着社会生活的发展,乳腺疾病逐渐成为女性最主要的健康问题。中医所述乳痈、乳癖、乳岩等病皆属于现代乳腺疾病范畴,且认为肝经与之最为密切。现代药理研究表明夏枯草含有萜类、酚酸类、黄酮类等多种生物活性成分,具有抗炎、抑菌、调节激素、抗肿瘤等作用。夏枯草通过抑制p38丝裂原活化蛋白激酶(p38 MAPK)/核转录因子-κB(NF-κB)通路以起到抗乳腺炎的作用,干预雌激素受体的作用效果或调节血脂水平以治疗乳腺增生,通过促进乳腺癌细胞凋亡、抑制乳腺癌细胞的迁移、调控乳腺癌细胞的分裂等多种方式协同作用发挥治疗乳腺癌的效果。在查阅夏枯草相关文献时,发现夏枯草往往通过多途径、多靶点调控发挥药理作用,但大部分的研究并未明确其发挥药效的具体靶点,有待后续深入研究。该综述对夏枯草治疗各类乳腺疾病的作用及其机制进行总结,为夏枯草在临床上发挥更加广泛的治疗作用及其治疗乳腺疾病作用的深入研究提供参考。
Prunellae Spica is the dry ear of the labiaceae plant Prunella vulgaris,which is a traditional medicine and food plant with many functions. Prunellae Spica can clear liver-fire,improve eyesight,disperse knot detumescence. It owns hot and bitter flavors and cold property. It goes to the liver,gallbladder meridian,and is a kind of commonly-used antifebric. Prunellae Spica has been used in the treatment of mammary gland diseases since ancient times. The mammary abscess,mammary nodules,mammary carcinoma of traditional Chinese medicine all belong to breast disease,and the liver meridian is most closely related to these diseases.With the development of social life,breast disease has gradually become the most primary health problem for women. Modern pharmacological studies show that Prunellae Spica contains terpenoids, phenolic acids,flavonoids and other biological active components, which have anti-inflammatory, antibacterial, hormone regulation, anti-tumor and other effects. Prunellae Spica inhibits the p38 mitogen-activated protein kinase(p38 MAPK)/nuclear factor kappa-B(NF-κB)pathway to play an anti-mastitis role,interferes with the effects of estrogen receptors or regulates lipid levels to treat breast hyperplasia,and treats breast cancer through promoting the apoptosis of breast cancer cells,inhibiting the migration of breast cancer cells,regulating the division of breast cancer cells and other ways. While referring to the relevant literature,it was found that Prunellae Spica often exerted pharmacological effects through multi-channels and multi-target regulation,but most of the studies did not specify the specific target of its effect,which needs further study. In this review,the effects and mechanisms of Prunellae Spica in the treatment of various breast diseases were summarized,so as to provide a reference for further research on the wider clinical therapeutic effects of Prunella subtilis and its therapeutic effects on breast diseases.
作者
刘盛旺
陈昳冰
林静怡
何峰
LIU Sheng-wang;CHEN Yi-bing;LIN Jing-yi;HE Feng(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine(TCM),Tianjin 300193,China;National Clinical Research Center for Chinese Medicine Acupuncture Moxibustion,Tianjin 300193,China;Li Shizhen College of TCM/Huanggang Normal University,Huanggang 438000,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2022年第5期250-255,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金青年基金项目(82104399)。
关键词
夏枯草
乳腺炎
乳腺增生
乳腺癌
药理作用
Prunellae Spica
mammitis
hyperplasia of mammary glands
mammary cancer
pharmacological action
