摘要
基质金属蛋白酶(matrix metalloproteinases,MMPs)是一大类锌依赖性内肽酶家族,主要由结缔组织合成,可降解细胞外基质(extracellular matrix,ECM)和基底膜,影响正常组织的再生和重建,参与恶性肿瘤的病理过程。基质金属蛋白酶-7(matrix metalloproteinase-7,MMP-7)是该家族中结构最小的成员,在身体的多个组织中均有表达,如甲状腺、乳腺、肺部、消化道、生殖系统、肝胆系统等。近年来,MMP-7在肝胆疾病中的作用越来越受到关注,研究发现MMP-7不仅在肝胆恶性肿瘤的生长、转移和侵袭过程中高表达;在肝脏纤维化、胆道闭锁等疾病中也异常升高,甚至可以作为胆道闭锁早期诊断的生物学标志物。
Matrix metalloproteinases(MMPs)are a large family of zinc-dependent endopeptidases,which are mainly synthesized by connective tissues,it can degrade the extracellular matrix(ECM)and basement membrane,affect the regeneration and reconstruction of normal tissues,and participate in the pathological process of malignant tumors.Matrix metalloproteinase-7(MMP-7)is the smallest member of the metalloproteinase family.It is expressed in many tissues of the body,such as thyroid,breast,lung,digestive tract,reproductive system and hepatobiliary system.In recent years,the expression of MMP-7 in hepatobiliary diseases has attracted more and more attention.MMP-7 is not only involved in the growth,metastasis and invasion process of hepatobiliary malignant tumors,but also highly expressed in liver fibrosis,biliary atresia and other diseases.This paper reviews the expression of MMP-7 in the above diseases.
作者
李玉红(综述)
许玲芬(审校)
Li Yuhong;Xu Lingfen(Department of Pediatric Gastroenterology,Shengjing Hospital of China Medical University,Shenyang 110004,China)
出处
《国际儿科学杂志》
2022年第1期48-51,共4页
International Journal of Pediatrics
关键词
基质金属蛋白酶-7
肝胆疾病
胆道闭锁
Matrix metalloproteinase-7
Hepatobiliary diseases
Biliary atresia
